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- W3031695384 abstract "ObjectiveTo study the effects of low-calcium dialysate on the calcium-phosphorus metabolism, parathyroid function and vascular calcifications in elderly patients with low turnover renal osteodystrophy undergoing maintenance hemodialysis (MHD).Methods80 MHD elderly patients (aged≥60 years) who were in stable condition over 6 months and with two consecutive serum intact parathyroid hormone (iPTH) <100 ng/L were observed for 12 months and randomly classified into the control group (calcium 1.50 mmol/L of dialysate, n=40) and the treatment group (calcium 1.25 mmol/L of dialysate, n=40). The changes of serum iPTH, calcium, phosphorus, calcium and phosphorus product and other indicators as well as related adverse reactions were observed and recorded before and 1, 3, 6 and 12 months after treatment. In addition, the intima-media thickness (IMT) of carotid artery and abdominal aorta calcification score (AACS) were measured in the patients before and 6 and 12 months after treatment.ResultsIn the treatment group, serum corrected calcium, phosphorus, and calcium-phosphate product began to decline after 1 month and a further decline at 3 months later, and serum iPTH level was significantly increased after 1 month and gradually increased at 3 months later. The above markers were stabilized after 6 months of treatment, and there were significant differences in the changes of the above markers before and after treatment (all P 0.05).ConclusionsThe low calcium dialysate (1.25 mmol/L) can prominently control the levels of serum calcium, phosphorus and calcium-phosphorus product, effectively improve the over-suppressed parathyroid function and vascular calcifications, and has a good security in elderly MHD patients with serum iPTH concentration <100 ng/L.Key words: Kidney failure, chronic; Hemodia filtration; Parathyroid hormone; Hemodialysis solutions" @default.
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- W3031695384 date "2015-05-14" @default.
- W3031695384 modified "2023-10-12" @default.
- W3031695384 title "Effect of low-calcium dialysate on low-turnover renal osteodystrophy in elderly patients with maintenance hemodialysis" @default.
- W3031695384 doi "https://doi.org/10.3760/cma.j.issn.0254-9026.2015.05.017" @default.
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