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- W3031696430 abstract "目的探讨pcEgr|IFNγ基因-放射联合治疗对移植黑色素瘤B16小鼠的抗肿瘤作用及其免疫学机理.方法肿瘤局部注射脂质体包裹的pcEgr|IFNγ重组质粒后36 h,接受20 Gy X射线照射,观察放疗后不同时间肿瘤大小,放疗后3 d瘤内IFN γ转录水平和15 d部分免疫学指标.结果pcEgr|IFNγ基因-放射联合治疗后第3～15天,肿瘤生长速率明显低于单纯照射组,照后第9～15天明显低于单纯基因治疗组和空质粒对照组;治疗后第3天,pcEgr|IFNγ基因-放射联合治疗组瘤内IFNγ表达水平明显高于单纯基因治疗组;脾脏NK细胞毒活性、IL-2和IFNγ分泌活性均明显高于单纯放疗组和单纯基因治疗组.结论 pcEgr|IFNγ基因-放射联合治疗抗肿瘤作用明显优于单纯放疗和单纯基因治疗组,其机理可能与放疗诱导瘤内IFNγ基因表达增强,激活荷瘤机体抗肿瘤免疫功能有关." @default.
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- W3031696430 date "2001-07-25" @default.
- W3031696430 modified "2023-09-25" @default.
- W3031696430 title "Experimentalal study on anti|tumor effect of pcEgr|IFNγ gene|radiotherapy" @default.
- W3031696430 doi "https://doi.org/10.3760/cma.j.issn.0254-5098.2001.04.002" @default.
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