Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031700699> ?p ?o ?g. }
- W3031700699 endingPage "4560" @default.
- W3031700699 startingPage "4546" @default.
- W3031700699 abstract "FTY720 is a treatment for relapsing remitting multiple sclerosis (MS). It is an analog of sphingosine-1-phosphate (S1P) and targets S1P receptors 1, 3, 4, and 5. Recent reports indicate an association between long-term exposure to FTY720 and cases of cryptococcal infection. Here, we studied the effect of FTY720 and its derivative, BAF312, which only target S1P receptors 1 and 5, in a mouse model of cryptococcal infection. We found that treatment with FTY720, but not with BAF312, led to decreased survival and increased organ burden in mouse cryptococcal granulomas. Both FTY720 and BAF312 caused a profound CD4+ and CD8+ T cell depletion in blood and lungs but only treatment with FTY720 led to cryptococcal reactivation. Treatment with FTY720, but not with BAF312, was associated with disorganization of macrophages and with M2 polarization at the granuloma site. In a cell system, FTY720 decreased phagocytosis and production of reactive oxygen species by macrophages, a phenotype recapitulated in the S1pr3-/- knockout macrophages. Our results suggest that FTY720 reactivates cryptococcosis from the granuloma through a S1P receptor 3-mediated mechanism and support the rationale for development of more-specific receptor modulators for therapeutic use of MS." @default.
- W3031700699 created "2020-06-05" @default.
- W3031700699 creator A5006808655 @default.
- W3031700699 creator A5010514395 @default.
- W3031700699 creator A5057386779 @default.
- W3031700699 creator A5062506013 @default.
- W3031700699 creator A5064137145 @default.
- W3031700699 creator A5068958380 @default.
- W3031700699 creator A5072537807 @default.
- W3031700699 creator A5080797961 @default.
- W3031700699 date "2020-07-27" @default.
- W3031700699 modified "2023-10-12" @default.
- W3031700699 title "FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages" @default.
- W3031700699 cites W1493585689 @default.
- W3031700699 cites W1763873242 @default.
- W3031700699 cites W1966404042 @default.
- W3031700699 cites W1966553763 @default.
- W3031700699 cites W1975061118 @default.
- W3031700699 cites W1975088467 @default.
- W3031700699 cites W1981879391 @default.
- W3031700699 cites W1990940065 @default.
- W3031700699 cites W1999868460 @default.
- W3031700699 cites W2005467120 @default.
- W3031700699 cites W2006985918 @default.
- W3031700699 cites W2020864348 @default.
- W3031700699 cites W2037123168 @default.
- W3031700699 cites W2039363748 @default.
- W3031700699 cites W2048784182 @default.
- W3031700699 cites W2062406170 @default.
- W3031700699 cites W2066565536 @default.
- W3031700699 cites W2073769659 @default.
- W3031700699 cites W2092814331 @default.
- W3031700699 cites W2099723019 @default.
- W3031700699 cites W2100317350 @default.
- W3031700699 cites W2100585903 @default.
- W3031700699 cites W2104281761 @default.
- W3031700699 cites W2105045932 @default.
- W3031700699 cites W2105192692 @default.
- W3031700699 cites W2105437852 @default.
- W3031700699 cites W2107649276 @default.
- W3031700699 cites W2108813293 @default.
- W3031700699 cites W2113619398 @default.
- W3031700699 cites W2137367279 @default.
- W3031700699 cites W2137891075 @default.
- W3031700699 cites W2146316044 @default.
- W3031700699 cites W2147432416 @default.
- W3031700699 cites W2148689819 @default.
- W3031700699 cites W2150639372 @default.
- W3031700699 cites W2154089780 @default.
- W3031700699 cites W2158014005 @default.
- W3031700699 cites W2158353135 @default.
- W3031700699 cites W2162742103 @default.
- W3031700699 cites W2166123227 @default.
- W3031700699 cites W2167876561 @default.
- W3031700699 cites W2171166905 @default.
- W3031700699 cites W2184498190 @default.
- W3031700699 cites W2209250550 @default.
- W3031700699 cites W2214472012 @default.
- W3031700699 cites W2293400205 @default.
- W3031700699 cites W2463013521 @default.
- W3031700699 cites W2476616202 @default.
- W3031700699 cites W2557233006 @default.
- W3031700699 cites W2591673243 @default.
- W3031700699 cites W2611697423 @default.
- W3031700699 cites W2753344384 @default.
- W3031700699 cites W2767816611 @default.
- W3031700699 cites W2789928935 @default.
- W3031700699 cites W2790123740 @default.
- W3031700699 cites W2791254460 @default.
- W3031700699 cites W2801695738 @default.
- W3031700699 cites W2876700675 @default.
- W3031700699 cites W2896520026 @default.
- W3031700699 cites W2902981441 @default.
- W3031700699 cites W2905941774 @default.
- W3031700699 cites W2926198215 @default.
- W3031700699 cites W4211092440 @default.
- W3031700699 doi "https://doi.org/10.1172/jci136068" @default.
- W3031700699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7456236" @default.
- W3031700699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32484801" @default.
- W3031700699 hasPublicationYear "2020" @default.
- W3031700699 type Work @default.
- W3031700699 sameAs 3031700699 @default.
- W3031700699 citedByCount "22" @default.
- W3031700699 countsByYear W30317006992020 @default.
- W3031700699 countsByYear W30317006992021 @default.
- W3031700699 countsByYear W30317006992022 @default.
- W3031700699 countsByYear W30317006992023 @default.
- W3031700699 crossrefType "journal-article" @default.
- W3031700699 hasAuthorship W3031700699A5006808655 @default.
- W3031700699 hasAuthorship W3031700699A5010514395 @default.
- W3031700699 hasAuthorship W3031700699A5057386779 @default.
- W3031700699 hasAuthorship W3031700699A5062506013 @default.
- W3031700699 hasAuthorship W3031700699A5064137145 @default.
- W3031700699 hasAuthorship W3031700699A5068958380 @default.
- W3031700699 hasAuthorship W3031700699A5072537807 @default.
- W3031700699 hasAuthorship W3031700699A5080797961 @default.
- W3031700699 hasBestOaLocation W30317006991 @default.
- W3031700699 hasConcept C160448771 @default.