Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031735441> ?p ?o ?g. }
- W3031735441 endingPage "90" @default.
- W3031735441 startingPage "37" @default.
- W3031735441 abstract "A sharp rise in osteoarthritis (OA) incidence is expected as over 25% of world population ages in the coming decade. Although OA is considered a degenerative disease, mounting evidence suggests a strong connection with chronic metabolic conditions and low-grade inflammation. OA pathology is increasingly understood as a complex interplay of multiple pathological events including oxidative stress, synovitis and immune responses revealing its intricate nature. Cellular, biochemical and molecular aspects of these pathological events along with major outcomes of the relevant research studies in this area are discussed in the present review. With reference to their published and unpublished work, the authors strongly propose synovitis as a central OA pathology and the key OA pathological events are described in connection with it. Recent research outcomes also have succeeded to establish a linkage between metabolic syndrome and OA, which has been precisely included in the present review. Impact of aging process cannot be neglected in OA. Cell senescence is an important mechanism of aging through which it facilitates development of OA like other degenerative disorders, also discussed within a frame of OA. Conclusively, the reviewers urge low-grade inflammation linked to aging and derailed immune function as a pathological platform for OA development and progression. Thus, interventions targeted to prevent inflammaging hold a promising potential in effective OA management and efforts should be invested in this direction." @default.
- W3031735441 created "2020-06-05" @default.
- W3031735441 creator A5027972164 @default.
- W3031735441 creator A5028777632 @default.
- W3031735441 creator A5051030808 @default.
- W3031735441 creator A5055312005 @default.
- W3031735441 creator A5066109851 @default.
- W3031735441 date "2021-01-01" @default.
- W3031735441 modified "2023-10-18" @default.
- W3031735441 title "Pathophysiological landscape of osteoarthritis" @default.
- W3031735441 cites W104976773 @default.
- W3031735441 cites W1486630806 @default.
- W3031735441 cites W151547172 @default.
- W3031735441 cites W1515504649 @default.
- W3031735441 cites W1525740558 @default.
- W3031735441 cites W1532612328 @default.
- W3031735441 cites W1558635903 @default.
- W3031735441 cites W1601218597 @default.
- W3031735441 cites W1763493942 @default.
- W3031735441 cites W1802748781 @default.
- W3031735441 cites W1829465060 @default.
- W3031735441 cites W1907180716 @default.
- W3031735441 cites W1919236313 @default.
- W3031735441 cites W1929515229 @default.
- W3031735441 cites W1935296231 @default.
- W3031735441 cites W1958579126 @default.
- W3031735441 cites W1965398132 @default.
- W3031735441 cites W1967136516 @default.
- W3031735441 cites W1967469609 @default.
- W3031735441 cites W1967857969 @default.
- W3031735441 cites W1968652079 @default.
- W3031735441 cites W1969088009 @default.
- W3031735441 cites W1971728117 @default.
- W3031735441 cites W1971918460 @default.
- W3031735441 cites W1975396356 @default.
- W3031735441 cites W1976164614 @default.
- W3031735441 cites W1979161900 @default.
- W3031735441 cites W1980409139 @default.
- W3031735441 cites W1981010982 @default.
- W3031735441 cites W1981022368 @default.
- W3031735441 cites W1981199758 @default.
- W3031735441 cites W1982142411 @default.
- W3031735441 cites W1982483937 @default.
- W3031735441 cites W1983290943 @default.
- W3031735441 cites W1983345459 @default.
- W3031735441 cites W1985399572 @default.
- W3031735441 cites W1989392302 @default.
- W3031735441 cites W1989696800 @default.
- W3031735441 cites W1990856586 @default.
- W3031735441 cites W1992479526 @default.
- W3031735441 cites W1998161526 @default.
- W3031735441 cites W1998313940 @default.
- W3031735441 cites W1999709426 @default.
- W3031735441 cites W2000010519 @default.
- W3031735441 cites W2001386939 @default.
- W3031735441 cites W2002154440 @default.
- W3031735441 cites W2002398009 @default.
- W3031735441 cites W2002966162 @default.
- W3031735441 cites W2003183149 @default.
- W3031735441 cites W2004297047 @default.
- W3031735441 cites W2005091462 @default.
- W3031735441 cites W2010802338 @default.
- W3031735441 cites W2011509273 @default.
- W3031735441 cites W2012548795 @default.
- W3031735441 cites W2013352191 @default.
- W3031735441 cites W2014458492 @default.
- W3031735441 cites W2017065497 @default.
- W3031735441 cites W2017223857 @default.
- W3031735441 cites W2017348165 @default.
- W3031735441 cites W2017854718 @default.
- W3031735441 cites W2018745984 @default.
- W3031735441 cites W2019147692 @default.
- W3031735441 cites W2019221616 @default.
- W3031735441 cites W2022494133 @default.
- W3031735441 cites W2022721848 @default.
- W3031735441 cites W2023173660 @default.
- W3031735441 cites W2025663995 @default.
- W3031735441 cites W2026172623 @default.
- W3031735441 cites W2027831505 @default.
- W3031735441 cites W2029355740 @default.
- W3031735441 cites W2029818075 @default.
- W3031735441 cites W2031753589 @default.
- W3031735441 cites W2032691826 @default.
- W3031735441 cites W2032806251 @default.
- W3031735441 cites W2035104435 @default.
- W3031735441 cites W2035242925 @default.
- W3031735441 cites W2036478416 @default.
- W3031735441 cites W2036943040 @default.
- W3031735441 cites W2037544224 @default.
- W3031735441 cites W2041480611 @default.
- W3031735441 cites W2041517292 @default.
- W3031735441 cites W2042166361 @default.
- W3031735441 cites W2042851093 @default.
- W3031735441 cites W2043914080 @default.
- W3031735441 cites W2044924856 @default.
- W3031735441 cites W2046712927 @default.
- W3031735441 cites W2047334057 @default.
- W3031735441 cites W2047703526 @default.