FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031741385> ?p ?o ?g. }

• W3031741385 endingPage "591" @default.
• W3031741385 startingPage "588" @default.
• W3031741385 abstract "Objective Background It generally accepted that spleen played complex role in the tumor immunity,which would change in the different periods of cancer. In this study, we investigate the changes in the functions of splenic macrophage (Mtp) in different stages of liver cancer induced by dieth- ylnitrosamine (DEN) in rats, to support the characteristics of two-way and phase of spleen in antitu-mor immunity. Methods Establishing the mode of pulmonary metastasis of liver cancer in forty male SD rat by diethylnitrosamine. In the 8th, 13 th and 16th week, 10 rats were randomly chosen and sacrificed, and divided into cirrhosis,liver cancer and pulmonary metastasis group depending on the pathology result, re-spectively. The other 10 rat were taken as control group. The Mω was isolated by anchoring cultivation. The changes in ultrastructure, phagocytosis, eytokine secretion, antigen processing and presenting, and viability of splenic Mω were detected by transmission electron microscope, VybrantTM Phagoeytosis Assay, DQTM Ovalbumin ,and httman TNF-α ELISpot kits. Results Under the electron microscope,the Mω in the control group had some prominences like pseudopodium, and mitochondria, ribosome, rough endoplasmic reticulum, lysosome can be found in the cytoplasm, and RBC phagocytosed. In the liver cirrhosis and liver cancer group, Mω had more prominences, meanwhile much more mitochondria, ribosome, rough endoplasmic retic-ulum, lysosome can be found in the cytoplasm, especially the liver cancer group. What is more, we can see the macrophage that is phagocytoseing or had phagocytosed other apoptosis and necrosis cells. In the pul- monary metastasis group,the Mω was swelling, with few organelle. As compared to the control group, thefunction of splenic Mω increased in cirrhosis and cancer group,but decreased in metastasis group (phago-cytosis rate:84.7±1.9,89.5±3.1 and 36.0±2.6 vs 75.6±1.7,P <0.05,P <0.01 ;viability: 1.53± 0. 15,1.56±0.14,and 1.12±0. 29 vs 1.48±0. 17, P < 0.05 ; TNF-α secretion: 741.0±52.9,1126. 2± 174.5 ,and 313.8±50.8 vs 626.6±24.6 ,P <0.05 ,P <0.01 ;positive cell rate of antigen processing and presenting:24.03±1.87,27.95±2.63,and 10.46±2.16 vs 16.45±1.86,P<0.01 ). Conclusion In the stage of cirrhosis and early cancer, the immune functions of splenic Mω were reinforcement. It may pro-mote the non-specificity tumor immunity. On opposite, in the stage of pulmonary metastasis, the immune functions of splenic Mω were impaired. It may lead to the decrease of tumor immunity.Key words: Carcinoma,hepatocellular;  Spleen;  Macrophage" @default.
• W3031741385 created "2020-06-05" @default.
• W3031741385 creator A5006008485 @default.
• W3031741385 creator A5030511983 @default.
• W3031741385 creator A5084939652 @default.
• W3031741385 date "2009-05-08" @default.
• W3031741385 modified "2023-09-27" @default.
• W3031741385 title "Changes in rats splenic macrophage during the process of live cancer induced by diethylnitrosamine" @default.
• W3031741385 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2009.05.015" @default.
• W3031741385 hasPublicationYear "2009" @default.
• W3031741385 type Work @default.
• W3031741385 sameAs 3031741385 @default.
• W3031741385 citedByCount "0" @default.
• W3031741385 crossrefType "journal-article" @default.
• W3031741385 hasAuthorship W3031741385A5006008485 @default.
• W3031741385 hasAuthorship W3031741385A5030511983 @default.
• W3031741385 hasAuthorship W3031741385A5084939652 @default.
• W3031741385 hasConcept C121608353 @default.
• W3031741385 hasConcept C126322002 @default.
• W3031741385 hasConcept C142724271 @default.
• W3031741385 hasConcept C158617107 @default.
• W3031741385 hasConcept C160448771 @default.
• W3031741385 hasConcept C16685009 @default.
• W3031741385 hasConcept C181199279 @default.
• W3031741385 hasConcept C202751555 @default.
• W3031741385 hasConcept C203014093 @default.
• W3031741385 hasConcept C2776231280 @default.
• W3031741385 hasConcept C2777214474 @default.
• W3031741385 hasConcept C2779013556 @default.
• W3031741385 hasConcept C2779244956 @default.
• W3031741385 hasConcept C2780216420 @default.
• W3031741385 hasConcept C2780931953 @default.
• W3031741385 hasConcept C28859421 @default.
• W3031741385 hasConcept C55493867 @default.
• W3031741385 hasConcept C71924100 @default.
• W3031741385 hasConcept C86803240 @default.
• W3031741385 hasConcept C95444343 @default.
• W3031741385 hasConcept C96232424 @default.
• W3031741385 hasConceptScore W3031741385C121608353 @default.
• W3031741385 hasConceptScore W3031741385C126322002 @default.
• W3031741385 hasConceptScore W3031741385C142724271 @default.
• W3031741385 hasConceptScore W3031741385C158617107 @default.
• W3031741385 hasConceptScore W3031741385C160448771 @default.
• W3031741385 hasConceptScore W3031741385C16685009 @default.
• W3031741385 hasConceptScore W3031741385C181199279 @default.
• W3031741385 hasConceptScore W3031741385C202751555 @default.
• W3031741385 hasConceptScore W3031741385C203014093 @default.
• W3031741385 hasConceptScore W3031741385C2776231280 @default.
• W3031741385 hasConceptScore W3031741385C2777214474 @default.
• W3031741385 hasConceptScore W3031741385C2779013556 @default.
• W3031741385 hasConceptScore W3031741385C2779244956 @default.
• W3031741385 hasConceptScore W3031741385C2780216420 @default.
• W3031741385 hasConceptScore W3031741385C2780931953 @default.
• W3031741385 hasConceptScore W3031741385C28859421 @default.
• W3031741385 hasConceptScore W3031741385C55493867 @default.
• W3031741385 hasConceptScore W3031741385C71924100 @default.
• W3031741385 hasConceptScore W3031741385C86803240 @default.
• W3031741385 hasConceptScore W3031741385C95444343 @default.
• W3031741385 hasConceptScore W3031741385C96232424 @default.
• W3031741385 hasIssue "05" @default.
• W3031741385 hasLocation W30317413851 @default.
• W3031741385 hasOpenAccess W3031741385 @default.
• W3031741385 hasPrimaryLocation W30317413851 @default.
• W3031741385 hasRelatedWork W1988150663 @default.
• W3031741385 hasRelatedWork W1995139611 @default.
• W3031741385 hasRelatedWork W2001836195 @default.
• W3031741385 hasRelatedWork W2017209306 @default.
• W3031741385 hasRelatedWork W2084553857 @default.
• W3031741385 hasRelatedWork W2122797654 @default.
• W3031741385 hasRelatedWork W2132898771 @default.
• W3031741385 hasRelatedWork W2135124093 @default.
• W3031741385 hasRelatedWork W218885823 @default.
• W3031741385 hasRelatedWork W2202450623 @default.
• W3031741385 hasRelatedWork W2297483425 @default.
• W3031741385 hasRelatedWork W2356968319 @default.
• W3031741385 hasRelatedWork W2391565288 @default.
• W3031741385 hasRelatedWork W2396295079 @default.
• W3031741385 hasRelatedWork W2538977980 @default.
• W3031741385 hasRelatedWork W2892887336 @default.
• W3031741385 hasRelatedWork W2896895997 @default.
• W3031741385 hasRelatedWork W3122826549 @default.
• W3031741385 hasRelatedWork W3199356250 @default.
• W3031741385 hasRelatedWork W2604320899 @default.
• W3031741385 hasVolume "26" @default.
• W3031741385 isParatext "false" @default.
• W3031741385 isRetracted "false" @default.
• W3031741385 magId "3031741385" @default.
• W3031741385 workType "article" @default.