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- W3031746688 abstract "Objective To investigate the efficacy and toxicities of GDP protocol combined with radiotherapy for refractory Non-hodgkin's lymphoma ( NHL ).Methods 43 patients with NHL who had received CHOP protocol for three cycles but not achieved complete response were randomly assigned to group with GDP alone or group with GDP plus radiotherapy.The response rate,rates of platelet and leukocyte inhibition,and recovery time to platelet and leukocyte after treatment were observed.Results Tthe overall response rate (PR+CR) was 22.7％ for the group with GDP alone and 66.7％ for the group with GDP plus radiotherapy ( x2=8.41,P＜ 0.01 ); leukocyte inhibition rate of grade Ⅲ or above was 22.7％ and 52.4％,respectively ( x 2=4.04,P ＜ 0.05 ); platelet inhibition rate of grades Ⅲ or above was 31.8％ and 42.8％ ( x2=0.56,P＞ 0.05 ); recovery time to platelet after therapy with C-CSF was ( 3.6 ± 1.5 ) days and ( 5.7 ± 2.3 ) days,respectively ( t=3.563,P＜ 0.01 ); and recovery time to platelet after treatment with IL-11 was ( 6.5 ± 2.6 ) days and ( 12.3 ± 4.1 ) days ( t =5.567,P ＜ 0.01 ).Conclusions GDP protocol combined with radiotherapy can enhance the overall response rate in patients with refractory Non-hodgkin's lymphoma.However,leukocyte inhibition rate of grade Ⅲ or above increases and recovery time to platelet and leukocyte prolongs.Key words: Refractory Non-hodgkin's lymphoma; GDP protocol; Radiotherapy" @default.
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- W3031746688 date "2011-10-01" @default.
- W3031746688 modified "2023-09-27" @default.
- W3031746688 title "The efficacy and toxicities of GDP protocol combined with radiotherapy for refractory Non-hodgkin's lymphoma" @default.
- W3031746688 doi "https://doi.org/10.3760/cma.j.issn.1007-1245.2011.19.003" @default.
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