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- W3031778113 abstract "ObjectiveTo explore the influence of long-term low-dose ionizing radiation on 8-hydroxy-2-deoxyguanosine(8-OHdG)level in the serum of radiation workers in hospitals.Methods307 age-and sex-matched hospital radiation workers were recruited by stratified random sampling method. After deleting the subjects without dosage information, 230 individuals were divided into four groups according to their job title [including diagnostic radiology(n=75), radiotherapy(n=60), nuclear medicine(n=41)and interventional radiology(n=54)]. Serum 8-OHdG level was measured by ELISA assay.ResultsAccording to the statistical analysis, there was significant difference in the serum 8-OHdG level among four groups (F=9.071, P<0.05), and the content of serum 8-OHdG was significantly higher in the interventional radiology group than that in the groups of diagnostic radiology, radiotherapy and nuclear medicine (t=-4.473, -3.011, -2.189, P<0.05). There were significant differences in serum 8-OHdG level among different dose groups and working period groups(F=7.659, 3.058, P<0.05). The serum 8-OHdG levels significantly increased along with exposure dose and working period(r=0.300, 0.142, P<0.05).ConclusionsSerum 8-OHdG may be a potential biomarker of oxidative DNA damage in radiation workers exposed to low-dose ionizing radiation.Key words: Ionizing radiation; Radiation workers; Interventional radiology; 8-hydroxy-2-deoxyguanosine" @default.
- W3031778113 created "2020-06-05" @default.
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- W3031778113 date "2018-04-25" @default.
- W3031778113 modified "2023-09-22" @default.
- W3031778113 title "Serum 8-hydroxy-2-deoxyguanosine level of radiation workers in hospitals" @default.
- W3031778113 doi "https://doi.org/10.3760/cma.j.issn.0254-5098.2018.04.003" @default.
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