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- W3031782085 abstract "目的 研究新生早产大鼠吸入高浓度氧(以下简称高氧)后肺组织细胞内细胞色素C(cytochrome C,Cytc)表达及分布的变化及其与肺细胞凋亡的关系,探讨Cytc变化在高氧肺损伤中的作用. 方法 将新生早产SD大鼠随机分为高氧组和空气组,高氧组暴露于浓度为85%左右的氧气中建立高氧肺损伤模型.在生后1、4、7、10、14 d各组取材,分别用RT-PCR技术检测肺组织Cytc和caspase-9 mRNA表达,用免疫组化法检测Cytc蛋白分布,脱氧核糖核酸转移酶介导的X-dUTP缺口末端标记(terminal deoxynucleotid transferase-mediated X-dUTP nick end labeling, TUNEL)法检测肺细胞凋亡情况. 结果 生后第4天高氧组肺组织Cytc mRNA水平为0.5739±0.0228,第7天为1.1000±0.1050,均高于空气组(分别为0.4001±0.0383和0.6330±0.0740)(P均＜0.05);高氧组肺组织caspase-9 mRNA第4天为1.2975±0.0729,第7天为1.2012±0.0615,也分别高于空气组(分别为0.8428±0.0272和0.8086±0.0167)(P＜0.05).生后各时间点肺组织Cytc免疫组化平均灰度值和肺组织细胞凋亡阳性率均高于空气组(P均＜0.01). 结论 高氧暴露可致新生早产大鼠肺组织Cytc mRNA表达增加和Cytc分布变化,可能通过激活caspase-9进而导致肺细胞凋亡,从而导致高氧肺损伤。" @default.
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- W3031782085 date "2007-03-16" @default.
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- W3031782085 title "Correlation between cytochrome C and the lung cell apoptosis in premature rats exposed to hyperoxia" @default.
- W3031782085 doi "https://doi.org/10.3760/cma.j.issn.1007-9408.2007.02.009" @default.
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