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- W3031796768 abstract "ObjectiveTo explore the effect of computer-aided cognitive training on cognitive function and auditory event-related potential P300 in patients with vascular cognitive impairment no dementia (VCIND).MethodsSixty VCIND patients were randomly divided into two groups namely a training group and a control group, each of 30. Both groups were given routine drug treatment and the traditional rehabilitation training. At the same time, the training group was additionally given 40min computer-aided cognitive training once a day, six times a week, lasing 4 weeks. Before and after four weeks of treatment, the cognitive function, the ability of daily life(ADL) and P300 of the two groups were assessed using mini-mental state examination(MMSE), the Montreal cognitive assessment (MoCA), Barthel Index (BI) and Motor evoked potential instrument respectively.ResultsBefore treatment, no significant difference was found in the average MoCA, MMSE and BI scores of the two groups. After treatment, improvement was observed in the total MoCA scores (22.40±4.38), as well as the average score, of visual space and executive function (3.27±0.58), attention (4.30±1.60), language(2.67±0.48), delayed memory (3.67±0.80), MMSE (22.03±3.55) and BI (82.17±11.28) in the training group compared with the control group. Before treatment, there was no significant difference in the P300 latency and amplitude between the two groups. After treatment, however, the P300 latency of the training group decreased to (352.1±30.68)ms, significantly lower than the control group [(356.45±40.30)ms] and that before treatment. Meanwhile, the amplitude rose to(8.65±1.18)μV, significantly higher than the control group [(8.65±1.18)μV] and that before treatment.ConclusionComputer-aided cognitive training can effectively improve the cognitive function of patients with VCIND and promote their ADL.Key words: Computer-aided cognitive training; Vascular cognitive impairment no dementia; MoCA; Auditory event-relate potential, P300" @default.
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- W3031796768 date "2015-05-25" @default.
- W3031796768 modified "2023-09-23" @default.
- W3031796768 title "Effect of computer-assisted cognitive training on cognitive function and P300 in patients with vascular cognitive impairment no dementia" @default.
- W3031796768 doi "https://doi.org/10.3760/cma.j.issn.0254-1424.2015.05.005" @default.
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