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- W3031796998 abstract "ObjectiveTo study the effects of cystic fibrosis transmembrane conductance regulator (CFTR) on neonatal rats with bronchopulmonary dysplasia (BPD).MethodThe hyperoxia (FiO2>90%)-induced neonatal BPD rat models were established and assigned into three groups: the model group, the agonist group and the antagonist group.Room air (FiO2 21%) was inhaled by the rats in the control group. 50 μl of phosphate buffered saline (PBS), genistein (50 mg/kg), arachidonic acid (500 mg/kg) and PBS were injected intraperitoneally respectively in the model group, the agonist group, the antagonist group and the control group at 24, 48 and 72 h after birth. The survival rates of the neonatal rats were calculated, the survival curves were drawn, the pathological changes of the lung tissues were examined (the control group and the model group: 3, 14 and 21 d after birth; the agonist group and antagonist group: 14 and 21 d after birth), and the expression of CFTR were studied using western blot method. The acute lung injury scores of the model group, the agonist group and the antagonist group were compared and the gray value was analyzed using Graphpad software.Result(1) The survival rates in the control group, the model group, the agonist group and the antagonist group were 96.8%, 93.3%, 100% and 34.5% respectively.The antagonist group had significantly lower survival rate than the other three groups (P 0.05). (3) The expressions of CFTR in the lungs were lower in the model group than the control group 3 d after birth (P 0.05). The CFTR expression was much higher in the agonist group than the model group (P 0.05).ConclusionCFTR may play a protective role in the pathogenesis of BPD.Key words: Bronchopulmonary dysplasia; Cystic fibrosis transmembrane conductance regulator; Agonist; Antagonist; Rats" @default.
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- W3031796998 date "2019-03-15" @default.
- W3031796998 modified "2023-09-23" @default.
- W3031796998 title "Effects of cystic fibrosis transmembrane conductance regulator on neonatal rats with bronchopulmonary dysplasia" @default.
- W3031796998 doi "https://doi.org/10.3760/cma.j.issn.2096-2932.2019.02.011" @default.
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