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- W3031835393 abstract "ObjectiveTo evaluate the effect of Xiaoyaosan and Shengmaiyin combined with conventional western medicine for xerophthalmia.MethodsA total of 76 xerophthalmia patients who met the criteria were divided into two groups according to random number table, with 38 cases in each group. The control group was treated with routine western medicine, while the observation group was treated with Xiaoyaosan combined with Shengmaiyin on the basis of the control group. Both groups were treated for 4 weeks. Before and after treatment, the symptoms were scored, and the tear film stability was evaluated according to the results of fluorescent test (FL), breakup time of tear film (BUT) and schirmer I test (SIT). The contents of IL-1β, IL-6 and TNF-α in tear were detected by ELISA, and the clinical efficacy was evaluated.ResultsThe total effective rate was 92.9% (65/70) in the observation group and 76.4% (55/72) in the control group, and there was significant difference between the two groups (Z=-2.991, P=0.002). After treatment, the SIT (6.9 ± 0.8 mm vs. 4.3 ± 0.5 mm, t=3.751), BUT (10.5 ± 1.6 s vs. 6.4 ± 0.8 s, t=4.228) in the observation group were significantly higher than those in the control group (P<0.05). The FL score (0.9 ± 0.1 vs. 1.4 ± 0.2, t=3.208) in the observation group was significantly lower than that of the control group (P<0.05). The scores of aningeresting, foreign body sensation, visual fatigue, photophobia and visual blur in the observation group were significantly lower than those in the control group (t were 3.559, 4.015, 4.119, 3.983, 4.120, all Ps<0.05). The levels of IL-1β, IL-6 and TNF-α in tear were significantly lower than those in control group (t were 11.887, 8.028, 8.112, all Ps<0.001).ConclusionsThe Xiaoyaosan combined with Shengmaiyin can improve tear film stability, relieve local ocular surface inflammation and improve clinical symptoms in patients with xerophthalmia.Key words: Xerophthalmia; Xiao Yao San; Sheng Mai San; Lacrimal apparatus diseases; Vision tests; Inflammatory reaction; Integrated Chinese traditional and western medicine therapy" @default.
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- W3031835393 date "2019-08-30" @default.
- W3031835393 modified "2023-09-28" @default.
- W3031835393 title "Clinical study of Xiaoyaosan and Shengmaiyin combined with conventional western medicine in the treatment of xerophthalmia" @default.
- W3031835393 doi "https://doi.org/10.3760/cma.j.issn.1673-4246.2019.08.008" @default.
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