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- W3031843548 abstract "目的 探讨糖皮质激素治疗前后葡萄膜炎患者外周血单核细胞(PBMC)培养上清液Th1/Th2细胞因子的变化.方法 应用酶联免疫吸附试验检测治疗前后葡萄膜炎患者PBMC上清液干扰素(IFN-γ)、白介素(IL)-2、IL-4和IL-10水平的变化,30例健康人作为正常对照.结果 急性葡萄膜炎患者PBMC上清液IFN-γ、IL-2、IL-4和IL-10水平与IFN-γ/IL-4、IFN-γ/IL-10比值明显高于恢复期患者和正常对照者(P=0.000).糖皮质激素治疗后,IFN-γ和IL-2水平、IFN-γ/IL-4和IFN-γ/IL-10比值降低(P=0.000),IL-10水平升高(P=0.000).治疗前不同类型葡萄膜炎组仅IFN-γ和IL-10水平差异有统计学意义(P＜0.01),治疗后IL-2、IL-4、IL-10和IFN-γ/IL-10比值差异有统计学意义(P＜0.05).治疗前后前葡萄膜炎和Vogt-小柳原田病患者除IL-4外,其余细胞因子及比值差异均有统计学意义(P＜0.05);Behcet病患者除IL-4和IL-10外,其余细胞因子及比值差异均有统计学意义(P＜0.01).治疗前后葡萄膜炎患者IFN-γ与IL-2水平间及IL-4与IL-10水平间呈正相关(P=0.000).结论 急性葡萄膜炎患者PBMC中Th1细胞因子显著升高并占优势,表明Th1/Th2细胞因子不平衡性与葡萄膜炎的发病有关。" @default.
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- W3031843548 date "2009-03-15" @default.
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- W3031843548 title "Effects of corticosteroids on Th1/Th2 cytokines in peripheral blood mononuclear cells in the patients with uveitis" @default.
- W3031843548 doi "https://doi.org/10.3760/cma.j.issn.2095-0160.2009.03.017" @default.
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