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- W3031858035 abstract "Objective To study the effect of apironolactone on the left ventricular remodeling(LVRM) in patients with acute myocardial infarction (AMI). Methods 90 patients with AMI were randomly divided into spironolactone group( n = 45 ) and control group( n = 45 ). Spironolactone 40mg/d was administered in addition to the routine treatment for spironolactone group; the control group was received the routine treatment. All patients with AMI were examined left ventficular end systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDD) and LVEF on 7 days and 90 days by ultrasonic cardiogram(UCG). Results Two groups patients with AMI in each UCG parameter had no significant difference on 7 days(P > 0.05); LVEDD, LVESD of spironolactone group on 90 days were significantly lower than that in control group(P < 0.05) and LVEF of spironolaetone groupwas significantly higher than that in control group(P < 0.05). Conclusion Those findings indicate that in patients with AMI, spironolactone may prevent LVRM.Key words: Spironolactone; Myocardial infarction; Ventricular remodeling" @default.
- W3031858035 created "2020-06-05" @default.
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- W3031858035 date "2008-06-28" @default.
- W3031858035 modified "2023-09-23" @default.
- W3031858035 title "Effect of spironolactone on the left ventricular remodeling in patients with acute myocardial infarction" @default.
- W3031858035 doi "https://doi.org/10.3760/cma.j.issn.1008-6706.2008.06.006" @default.
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