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- W3031866581 abstract "目的研究烧伤动物缺锌状况,通过不同剂量、不同途径补锌观察对创面愈合的影响.方法 Wistar大鼠80只,以沸水烫伤8秒致15%深Ⅱ度烫伤,设正常对照组(C组),通过经口和创面补锌者3组,分别以正常含锌饲料(40 mg/kg,N组)、高锌饲料(80 mg/kg,H组)喂养,正常含锌饲料加创面涂银锌霜(含锌761 mg/kg,W组),于伤后1、3、7天活杀动物取血,检查血清锌含量和生长激素(GH)水平,取烫伤皮肤检测组织中的锌含量和羟脯氨酸(OHP)水平.另设2组大鼠,对比外用银锌霜或碘伏后创面愈合过程. 结果伤后第1天血锌、皮肤锌及OHP即明显降低,血GH略有升高,饲以高锌饲料可以尽快提高血锌、皮肤锌和血GH水平,经创面补锌可以提高皮肤锌、皮肤OHP含量,有助于加速创面修复.在创面愈合过程的对比中发现,应用银锌霜的深Ⅱ度创面(12.3±2.1)d即愈合,而对照组至21 d只有66.7%的创面愈合. 结论烧伤后血锌、皮肤锌及皮肤OHP水平都降低,经口饲和创面补锌可提高上述水平,口饲补锌侧重于提高血锌和GH水平,创面补锌有助于增加皮肤中锌和OHP含量,且能促进创面愈合." @default.
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- W3031866581 date "2001-08-30" @default.
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- W3031866581 title "Experimental study on the effect of zinc nutritive status on repair of burn wound" @default.
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