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- W3031871849 abstract "The bombesin-like receptor subtype -3 (BRS-3), a member of the bombesin-like receptor family, is a G-protein coupled receptor mainly found in the central nervous system and peripheral tissues. The study found that BRS-3 gene knockout mice had impaired glucose metabolism, decreased basal metabolic rate, increased food intake and absorption, weight gain, increased insulin secretion, insulin resistance, mild hypertension and a series of metabolic changes. In patients with type 2 diabetes mellitus and obesity, the expression of BRS-3 mRNA and protein in adipocytes, skeletal muscle cells have decreased. Studies found that BRS-3 agonists could stimulate insulin secretion, increase basal metabolic rate, which may provide a new insight for the treatment of metabolic disease such as obesity, type 2 diabetes.Key words: Bombesin receptor subtype-3; Type 2 diabetes mellitus; Obesity; Metabolic syndrome" @default.
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- W3031871849 date "2018-05-20" @default.
- W3031871849 modified "2023-09-28" @default.
- W3031871849 title "Bombesin receptor subtype-3 and metabolic syndrome" @default.
- W3031871849 doi "https://doi.org/10.3760/cma.j.issn.1673-4157.2018.03.008" @default.
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