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- W3031873658 abstract "ObjectiveTo investigate the role of pDCs and CD4+ CD25+ Treg cells in the mechanism of immune-tolerant chronic HBV infection.Methods12 patients with immune-tolerant chronic HBV infection and 6 patients in recovery period of acute hepatitis B were examined. Frequencies and expression of CD80/CD83/CD86 of pDCs and Frequencies of Treg cells in peripheral blood were detected by flow cytometry. Plasma cytokines IFN-α2, IFN- gamma, TGF- alpha, FLT-3L, IL-10, IL-6, IL-17A were measured by Luminex.ResultsFrequencies and expression of CD80/CD83/CD86 of pDCs in immune tolerance group were similar to the resolved acute HBV infection group, but the level of plasma IFN- alpha 2 was significantly higher than that in acute hepatitis B recovery group.Frequencies of Treg cells and cytokines IL-10 in immune-tolerant group was also significantly higher than that in acute hepatitis B recovery group.ConclusionThe number and function of pDCs in chronic HBV infection immune tolerance group was normal, while Treg cells and IL-10 with a significant increase.Key words: Hepatitis B; Dendritic cells; T-Lympha cytes; Interloukin-10; Interferon-alpha" @default.
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- W3031873658 date "2015-06-30" @default.
- W3031873658 modified "2023-09-24" @default.
- W3031873658 title "Study the role of regulatory T cells in the mechanism of immune tolerance in chronic HBV infection" @default.
- W3031873658 doi "https://doi.org/10.3760/cma.j.issn.1003-9279.2015.03.002" @default.
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