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• W3031903653 abstract "Objective To analyze the detection rate of HBV serological makers in non-hepatic inpatients in the past six years. Methods Serum samples of 70 582 non-hepatic inpatients from three large hospitals were collected during 2003 to 2008. Serological markers of HBV ( anti-HBs, HBeAg, antiHBe and anti-HBc) were detected by the AxSYM MEIA system (Abbott Laboratories,Abbott Park,IL).Combining the test results of serological makers with other clinical data, several analysis models for this retrospective study were set up to evaluate the year-to-year changes in serological makers and the detection rates of each model. Results The order from high to low of detection rate of the 5 HBV serological markers was (55. 17% ), (49. 57% ), anti-HBe (28.42%), HBsAg ( 8. 92% ) and HBeAg (2. 12% ), and all of them had a downward trend in the past six years. The positive rate of HBsAg went down from 9. 30% (2003) to 8.70% (2008). The positive rate of HBsAg among people who were born after 1992 (2. 28% ) were significantly lower than that of the overall population (8. 92% ) and fell from 3.57%(2003) to 1.85% (2008). Each detection rate of all serological makers had male sexual side effect [HBsAg ( 12. 38%/7. 25% ), HBeAg ( 2. 72%/1.58% ), ( 56. 57%/53.43% ), anti-HBe (41.50%/28. 35% ) and (65.48%/50. 00% ), male/female]. The differences were statistically significant (Chi-square values of HBeAg, anti-HBc, anti-HBe and were 509.74,105.78, 69.66, 1 321.61 and 1 726.91, respectively; all P ＜ 0. 01).Twenty-six models of HBV serological makers from 70 582 inpatients were summed up, and 8 models had positive rates geater than or equal to 1%. The All Negative model ranked No. 1 and had no significant change from year to year. During the past six years, models representing A11 Negative and anti-HBs alone were mainly in individuals younger than or equal to 20-year-old, while the models representing anti-HBc and/or anti-HBe,anti-HBs Positive were mostly in people older than 20-year-old. The distribution curve of models representing HBsAg, HbeAg and Positive and HBsAg, anti-HBc, anti-HBe Positiveetc. showed a bell-shape, covering the population from 20-year-old to 70-year-old. Conclusions The slowlydescending tendency of the detection rates of HBV serological makers was observed during the past six years.The detection rates of HBV in the younger generation decreased significantly. However, the HBV infection rates of overall population is still high, so it is a high time that we made continuous improvement for the serum HBV screening technique in order to reduce the HBV infection ratess.Key words: Hepatitis B virus; Hepatitis B antigens; Biological markers; Immunoenzyme techniques; Retrospective studies" @default.
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• W3031903653 date "2010-10-11" @default.
• W3031903653 modified "2023-09-23" @default.
• W3031903653 title "Retrospective analysis of hepatitis B virus serological markers in 70 582 inpatients" @default.
• W3031903653 doi "https://doi.org/10.3760/cma.j.issn.1009-9158.2010.10.005" @default.
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