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- W3031904935 abstract "ObjectiveTo investigate the effect of thrombelastography (TEG) on the anticoagulant efficacy of rivaroxaban by dynamically detecting common coagulation function and TEG at different time intervals before and after oral administration of rivaroxaban in patients with venous thromboembolism (VTE).MethodsA total of 80 patients with a diagnosis of acute lower extremities deep vein thrombosis(DVT) who were admitted to the department of vascular surgery, Shanxi Dayi Hospital during March 2017 to November 2017 were enrolled into this study. All patients received routine rivaroxaban tablets orally for their out-of-hospital anticoagulation regimens. During three months of follow-up, no massive haemorrhage or visceral haemorrhage or recurrence of thrombosis event occurred. Univariate analysis was conducted to analyze the changes of coagulation test and TEG among four different time points (pre-coagulation, three days-, one month- and three month after rivaroxaban coagulation therapy).ResultsR value, K value, and PT value were significantly increased while D-dimer value was decreased after administrated of rivaroxaban compared with pre-coagulation (P 0.05). In comparison among different time points post-coagulation, there was no significant difference of PT, R and K values in each groups (P>0.05).ConclusionsR value and K value of TEG test are prolonged after oral administration of rivaroxaban in patients with VTE, which can be used as a means to monitor the anticoagulation efficacy of rivaroxaban.Key words: Rivaroxaban; Anticoagulation; Coagulation monitoring; Thrombelastography" @default.
- W3031904935 created "2020-06-05" @default.
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- W3031904935 date "2019-05-31" @default.
- W3031904935 modified "2023-09-23" @default.
- W3031904935 title "Analysis of anticoagulation efficacy by thrombelastography for oral rivaroxaban in patients with venous thromboembolism" @default.
- W3031904935 doi "https://doi.org/10.3760/cma.j.issn.2096-1863.2019.02.008" @default.
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