FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031905776> ?p ?o ?g. }

• W3031905776 endingPage "345" @default.
• W3031905776 startingPage "331" @default.
• W3031905776 abstract "Dynein is a cytoskeletal molecular motor protein that moves along the microtubule (MT) and transports various cellular cargos during its movement. Using standard Molecular Dynamics (MD) simulation, Principle Component Analysis (PCA), and Normal Mode Analysis (NMA) methods, this investigation studied large-scale movements and local interactions of dynein’s Microtubule Binding Domain (MTBD) when bound to tubulin heterodimer subunits. Examination of the interactions between the MTBD segments, and their adjustments in terms of intra- and intermolecular distances at the interfacial area with tubulin heterodimer, particularly at α-H16, β-H18, and β-tubulin C-terminal tail (CTT), was the main focus of this study. The specific intramolecular interactions, electrostatic forces, and the salt bridge residue pairs were shown to be the dominating factors in orchestrating movements of the MTBD and MT interfacial segments in the dynein’s low-high-affinity binding modes. Important interactions included β-Glu447 and β-Glu449 (CTT) with Arg3469 (MTBD-H6), Lys3472 (MTBD-H6-H7 loop) and Lys3479 (MTBD-H7); β-Glu449 with Lys3384 (MTBD-H8), Lys3386 and His3387 (MTBD-H1). The structural and precise position, orientation, and functional effects of the CTTs on the MT-MTBD, within reasonable cut-off distance for non-bonding interactions and under physiological conditions, are unavailable from previous studies. The absence of the residues in the highly flexible MT-CTTs in the experimentally solved structures is perhaps in some cases due to insufficient data from density maps, but these segments are crucial in protein binding. The presented work contributes to the information useful for the MT-MTBD structure refinement." @default.
• W3031905776 created "2020-06-05" @default.
• W3031905776 creator A5012138462 @default.
• W3031905776 creator A5041557461 @default.
• W3031905776 date "2020-05-27" @default.
• W3031905776 modified "2023-10-03" @default.
• W3031905776 title "C-terminal Tail of β-Tubulin and its Role in the Alterations of Dynein Binding Mode" @default.
• W3031905776 cites W1567621547 @default.
• W3031905776 cites W1663217888 @default.
• W3031905776 cites W1961325350 @default.
• W3031905776 cites W1964074623 @default.
• W3031905776 cites W1966078827 @default.
• W3031905776 cites W1974025012 @default.
• W3031905776 cites W1990343615 @default.
• W3031905776 cites W1995816895 @default.
• W3031905776 cites W1998412941 @default.
• W3031905776 cites W2001632155 @default.
• W3031905776 cites W2003477962 @default.
• W3031905776 cites W2014860300 @default.
• W3031905776 cites W2023047993 @default.
• W3031905776 cites W2035687084 @default.
• W3031905776 cites W2037091801 @default.
• W3031905776 cites W2057477511 @default.
• W3031905776 cites W2058997498 @default.
• W3031905776 cites W2060259273 @default.
• W3031905776 cites W2064047527 @default.
• W3031905776 cites W2064571598 @default.
• W3031905776 cites W2066926304 @default.
• W3031905776 cites W2078352395 @default.
• W3031905776 cites W2081231020 @default.
• W3031905776 cites W2084476197 @default.
• W3031905776 cites W2095724872 @default.
• W3031905776 cites W2105615050 @default.
• W3031905776 cites W2121439726 @default.
• W3031905776 cites W2123487350 @default.
• W3031905776 cites W2126023465 @default.
• W3031905776 cites W2128572087 @default.
• W3031905776 cites W2128622000 @default.
• W3031905776 cites W2132589721 @default.
• W3031905776 cites W2133433041 @default.
• W3031905776 cites W2137983120 @default.
• W3031905776 cites W2148881591 @default.
• W3031905776 cites W2157961198 @default.
• W3031905776 cites W2171268876 @default.
• W3031905776 cites W2415698324 @default.
• W3031905776 cites W2602849150 @default.
• W3031905776 cites W2800287140 @default.
• W3031905776 cites W2802503852 @default.
• W3031905776 cites W2889168357 @default.
• W3031905776 cites W2964507132 @default.
• W3031905776 cites W4237238549 @default.
• W3031905776 doi "https://doi.org/10.1007/s12013-020-00920-7" @default.
• W3031905776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32462384" @default.
• W3031905776 hasPublicationYear "2020" @default.
• W3031905776 type Work @default.
• W3031905776 sameAs 3031905776 @default.
• W3031905776 citedByCount "7" @default.
• W3031905776 countsByYear W30319057762021 @default.
• W3031905776 countsByYear W30319057762022 @default.
• W3031905776 countsByYear W30319057762023 @default.
• W3031905776 crossrefType "journal-article" @default.
• W3031905776 hasAuthorship W3031905776A5012138462 @default.
• W3031905776 hasAuthorship W3031905776A5041557461 @default.
• W3031905776 hasBestOaLocation W30319057761 @default.
• W3031905776 hasConcept C106987784 @default.
• W3031905776 hasConcept C107824862 @default.
• W3031905776 hasConcept C121332964 @default.
• W3031905776 hasConcept C12554922 @default.
• W3031905776 hasConcept C142669718 @default.
• W3031905776 hasConcept C1491633281 @default.
• W3031905776 hasConcept C166950319 @default.
• W3031905776 hasConcept C178790620 @default.
• W3031905776 hasConcept C185592680 @default.
• W3031905776 hasConcept C20418707 @default.
• W3031905776 hasConcept C32909587 @default.
• W3031905776 hasConcept C55493867 @default.
• W3031905776 hasConcept C8010536 @default.
• W3031905776 hasConcept C84425145 @default.
• W3031905776 hasConcept C86803240 @default.
• W3031905776 hasConcept C93126451 @default.
• W3031905776 hasConcept C95444343 @default.
• W3031905776 hasConceptScore W3031905776C106987784 @default.
• W3031905776 hasConceptScore W3031905776C107824862 @default.
• W3031905776 hasConceptScore W3031905776C121332964 @default.
• W3031905776 hasConceptScore W3031905776C12554922 @default.
• W3031905776 hasConceptScore W3031905776C142669718 @default.
• W3031905776 hasConceptScore W3031905776C1491633281 @default.
• W3031905776 hasConceptScore W3031905776C166950319 @default.
• W3031905776 hasConceptScore W3031905776C178790620 @default.
• W3031905776 hasConceptScore W3031905776C185592680 @default.
• W3031905776 hasConceptScore W3031905776C20418707 @default.
• W3031905776 hasConceptScore W3031905776C32909587 @default.
• W3031905776 hasConceptScore W3031905776C55493867 @default.
• W3031905776 hasConceptScore W3031905776C8010536 @default.
• W3031905776 hasConceptScore W3031905776C84425145 @default.
• W3031905776 hasConceptScore W3031905776C86803240 @default.
• W3031905776 hasConceptScore W3031905776C93126451 @default.
• W3031905776 hasConceptScore W3031905776C95444343 @default.

• next