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- W3031917650 abstract "Using the sensitive reverse transcription polymerase chain reaction (RT-PCR), IL-12 mRNA expression in the pre-rejecting murine heart allograft as well as IL-2 were determined. One week treatment of FK506 at the dosage of 3 mg/kg per day prolonged allogeneic graft survival to 11.9±2.4 days compared to control animals given the vehile alone (7.0±0.7 days, P <0.01). There was upregutation of both IL-12 and IL-2 mRNA in the heart allograft and that of IL-2 in the recipient's spleen. Both IL-2 and IL-12 mRNA in murine heart allografts were suppressed by FK506, while IL-12 in the recipient's spleen was spared. It was considered tha the antitumor immunity mediated by NK cells may be spared.Key words: RT-PCR; FK506; Heart /transplantation; Cytokine" @default.
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- W3031917650 date "1997-09-20" @default.
- W3031917650 modified "2023-09-25" @default.
- W3031917650 title "FK506 inhibits the expression of IL-12 mRNA in murine heart allograft" @default.
- W3031917650 doi "https://doi.org/10.3760/cma.j.issn.0254-1785.1997.03.019" @default.
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