FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031934460> ?p ?o ?g. }

• W3031934460 abstract "Abstract Spontaneous neuronal and astrocytic activity in the neonate forebrain is believed to drive the maturation of individual cells and their integration into complex brain-region-specific networks. The previously reported forms include bursts of electrical activity and oscillations in intracellular Ca 2+ concentration. Here, we use ratiometric Na + imaging to demonstrate spontaneous fluctuations in the intracellular Na + concentration of CA1 pyramidal neurons and astrocytes in tissue slices obtained from the hippocampus of mice at postnatal days 2-4 (P2-4). These occur at very low frequency (∼2/h), can last minutes with amplitudes up to several mM, and mostly disappear after the first postnatal week. To further study the mechanisms that may generate such spontaneous fluctuations in neurons, we model a network consisting of pyramidal neurons and interneurons. Experimentally observed Na + fluctuations are mimicked when GABAergic inhibition in the simulated network is inverted. Both our experiments and computational model show that the application of tetrodotoxin to block voltage-gated Na + channels or of inhibitors targeting GABAergic signaling respectively, significantly diminish the neuronal Na + fluctuations. On the other hand, blocking a variety of other ion channels, receptors, or transporters including glutamatergic pathways, does not have significant effects. In addition, our model shows that the amplitude and duration of Na + fluctuations decrease as we increase the strength of glial K + uptake. Furthermore, neurons with smaller somatic volumes exhibit fluctuations with higher frequency and amplitude. As opposed to this, the larger relative size of the extracellular with respect to intracellular space observed in neonatal brain exerts a dampening effect. Finally, our model also predicts that these periods of spontaneous Na + influx leave neonatal neuronal networks more vulnerable to hyperactivity when compared to mature brain. Taken together, our model thus confirms the experimental observations, and offers additional insight into how the neonatal environment shapes early signaling in the brain. Author Summary Spontaneous neuronal and astrocytic activity during the early postnatal period is crucial to the development and physiology of the neonate forebrain. Elucidating the origin of this activity is key to our understanding of the cell maturation and formation of brain-region-specific networks. This study reports spontaneous, ultraslow, large-amplitude, long-lasting fluctuations in the intracellular Na + concentration of neurons and astrocytes in the hippocampus of mice at postnatal days 2-4 that mostly disappear after the first postnatal week. We combine ratiometric Na + imaging and pharmacological manipulations with a detailed computational model of neuronal networks in the neonatal and adult brain to provide key insights into the origin of these Na + fluctuations. Furthermore, our model predicts that these periods of spontaneous Na + influx leave neonatal neuronal networks more vulnerable to hyperactivity when compared to mature brain." @default.
• W3031934460 created "2020-06-05" @default.
• W3031934460 creator A5004662891 @default.
• W3031934460 creator A5015322241 @default.
• W3031934460 creator A5053344071 @default.
• W3031934460 creator A5083123719 @default.
• W3031934460 date "2020-05-29" @default.
• W3031934460 modified "2023-09-25" @default.
• W3031934460 title "On the Origin of Ultraslow Spontaneous Na+ Fluctuations in Neurons of the Neonatal Forebrain" @default.
• W3031934460 cites W1134182094 @default.
• W3031934460 cites W1489033370 @default.
• W3031934460 cites W1501360999 @default.
• W3031934460 cites W1508839941 @default.
• W3031934460 cites W1529045620 @default.
• W3031934460 cites W1554045794 @default.
• W3031934460 cites W1575530593 @default.
• W3031934460 cites W1588629441 @default.
• W3031934460 cites W1594253922 @default.
• W3031934460 cites W160507194 @default.
• W3031934460 cites W1735445987 @default.
• W3031934460 cites W1768736801 @default.
• W3031934460 cites W1963806203 @default.
• W3031934460 cites W1975196303 @default.
• W3031934460 cites W1975934006 @default.
• W3031934460 cites W1992792117 @default.
• W3031934460 cites W1998240840 @default.
• W3031934460 cites W2001248841 @default.
• W3031934460 cites W2003600785 @default.
• W3031934460 cites W2018481821 @default.
• W3031934460 cites W2037279364 @default.
• W3031934460 cites W2042443704 @default.
• W3031934460 cites W2043437580 @default.
• W3031934460 cites W2046686563 @default.
• W3031934460 cites W2047867249 @default.
• W3031934460 cites W2051470122 @default.
• W3031934460 cites W2052792709 @default.
• W3031934460 cites W2056147691 @default.
• W3031934460 cites W2059743066 @default.
• W3031934460 cites W2065493307 @default.
• W3031934460 cites W2069963369 @default.
• W3031934460 cites W2076462587 @default.
• W3031934460 cites W2085116630 @default.
• W3031934460 cites W2085503685 @default.
• W3031934460 cites W2088115551 @default.
• W3031934460 cites W2101067109 @default.
• W3031934460 cites W2106495485 @default.
• W3031934460 cites W2109611921 @default.
• W3031934460 cites W2110169026 @default.
• W3031934460 cites W2117329255 @default.
• W3031934460 cites W2117770051 @default.
• W3031934460 cites W2126578880 @default.
• W3031934460 cites W2132282183 @default.
• W3031934460 cites W2132403112 @default.
• W3031934460 cites W2137730912 @default.
• W3031934460 cites W2152472106 @default.
• W3031934460 cites W2153775014 @default.
• W3031934460 cites W2155965080 @default.
• W3031934460 cites W2167368466 @default.
• W3031934460 cites W2167970717 @default.
• W3031934460 cites W2172266256 @default.
• W3031934460 cites W2258821072 @default.
• W3031934460 cites W2300320813 @default.
• W3031934460 cites W2328001100 @default.
• W3031934460 cites W2543379321 @default.
• W3031934460 cites W2737379596 @default.
• W3031934460 cites W2745891242 @default.
• W3031934460 cites W2759536331 @default.
• W3031934460 cites W2762830304 @default.
• W3031934460 cites W2902418286 @default.
• W3031934460 cites W2915076599 @default.
• W3031934460 cites W2950279742 @default.
• W3031934460 cites W2976030144 @default.
• W3031934460 cites W3011621535 @default.
• W3031934460 cites W3024974868 @default.
• W3031934460 cites W37795517 @default.
• W3031934460 doi "https://doi.org/10.1101/2020.05.29.123026" @default.
• W3031934460 hasPublicationYear "2020" @default.
• W3031934460 type Work @default.
• W3031934460 sameAs 3031934460 @default.
• W3031934460 citedByCount "0" @default.
• W3031934460 crossrefType "posted-content" @default.
• W3031934460 hasAuthorship W3031934460A5004662891 @default.
• W3031934460 hasAuthorship W3031934460A5015322241 @default.
• W3031934460 hasAuthorship W3031934460A5053344071 @default.
• W3031934460 hasAuthorship W3031934460A5083123719 @default.
• W3031934460 hasBestOaLocation W30319344601 @default.
• W3031934460 hasConcept C12554922 @default.
• W3031934460 hasConcept C169760540 @default.
• W3031934460 hasConcept C170493617 @default.
• W3031934460 hasConcept C17077164 @default.
• W3031934460 hasConcept C185592680 @default.
• W3031934460 hasConcept C2776741303 @default.
• W3031934460 hasConcept C2779177108 @default.
• W3031934460 hasConcept C2779715522 @default.
• W3031934460 hasConcept C2780648746 @default.
• W3031934460 hasConcept C2781161787 @default.
• W3031934460 hasConcept C28406088 @default.
• W3031934460 hasConcept C529278444 @default.
• W3031934460 hasConcept C55493867 @default.
• W3031934460 hasConcept C61174792 @default.

• next