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- W3031941368 abstract "目的 通过分析角膜移植排斥反应的免疫病理改变,探讨移植失败的相关因素.方法 角膜移植术后排斥反应的患者42例,于再次行穿通性角膜移植术时取其排斥的移植片,进行免疫组化及HE染色,观察术后排斥反应的移植片中巨噬细胞、CD4+和CD8+细胞的浸润和分布、MHC-Ⅱ类主要组织相容性抗原、白介素受体-2和转化生长因子-β的表达,以及移植片的组织病理学改变.结果 42例移植片均有上述免疫细胞的表达,并以新生血管周围更加明显;这些细胞表达MHC-Ⅱ类抗原和IL-2R;移植片的上皮和基质细胞中也有MHC-Ⅱ类抗原的表达;角膜上皮细胞可表达TGF-β;所有移植片内皮细胞均不完整甚至大部缺如.结论 新生血管使免疫细胞进入移植片,破坏免疫赦免机制,与移植片免疫损害密切相关;免疫细胞和分子直接导致移植片免疫损伤,内皮细胞的严重损伤终将导致移植失败。" @default.
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- W3031941368 date "2006-12-10" @default.
- W3031941368 modified "2023-09-25" @default.
- W3031941368 title "Immunopathologic studies of corneal transplant rejection" @default.
- W3031941368 doi "https://doi.org/10.3760/cma.j.issn.1006-4443.2006.12.008" @default.
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