Matches in SemOpenAlex for { <https://semopenalex.org/work/W3031946210> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3031946210 endingPage "468" @default.
- W3031946210 startingPage "465" @default.
- W3031946210 abstract "Objective To investigate the effects of lipoxin A4 (LXA4) on the inflammatory response to focal cerebral ischemia-reperfusion(I/R) inmy in rats.Methods Fifty-six healthy male SD rats weighing 200-250 g were randomly divided into 3 groups:group Ⅰ sham operation(group S,n=8);group Ⅱ cerebral I/R(n=24)and group Ⅲ lipoxin A4+I/R(group LXA4,n=24).Right mid-cerebral artery was occluded for 2 h by inserting cranially a nylon thread with rounded tip into internal carotid artery.LXA4 0.03 nmol/5 μl was injected into cerebral ventricle at 5 min after cerebral ischemia.Neurological deficit was scored at 24 h of reperfusion.Then four animals in each group were killed and their brains were removed for microscopic examination and expression of MPO at 24 h of reperfusion.Meantime,content of IL-1β,TNF-α,TGF-β1,and IL-10 in the brain tissue were measured at 1,6,12,24 and 48 h of reperfusion by ELISA.Glial cell activity was examined at 24 h of reperfusion by immuno-histochemistry.Results Intra-cerebroventricular administrated LXA4 0.03 nmol/5 μl provided mild neuroprotection against focal cerebral I/R injury,improved neurological deficits,and reduced morphological brain damages and PMN infiltration.LXA4 also decreased the content of TNF-α and IL-1β,and increased the content of IL-10 and TGF-β1.The numbers of activated astroglia and microglia were decreased in group LXA4 compared with group I/R.Conclusion LXA4 protects the brain against I/R injury by inhibiting inflammatory response.Key words: Lipoxins; Brain ischemia; Repedusion injury; Inflammation" @default.
- W3031946210 created "2020-06-05" @default.
- W3031946210 creator A5003409121 @default.
- W3031946210 creator A5028770021 @default.
- W3031946210 creator A5067893036 @default.
- W3031946210 creator A5080857173 @default.
- W3031946210 date "2010-04-20" @default.
- W3031946210 modified "2023-09-23" @default.
- W3031946210 title "Effects of lipoxin A4 on inflammatory response to focal cerebral ischemia-reperfusion injury in rats" @default.
- W3031946210 doi "https://doi.org/10.3760/cma.j.issn.0254-1416.2010.04.025" @default.
- W3031946210 hasPublicationYear "2010" @default.
- W3031946210 type Work @default.
- W3031946210 sameAs 3031946210 @default.
- W3031946210 citedByCount "0" @default.
- W3031946210 crossrefType "journal-article" @default.
- W3031946210 hasAuthorship W3031946210A5003409121 @default.
- W3031946210 hasAuthorship W3031946210A5028770021 @default.
- W3031946210 hasAuthorship W3031946210A5067893036 @default.
- W3031946210 hasAuthorship W3031946210A5080857173 @default.
- W3031946210 hasConcept C126322002 @default.
- W3031946210 hasConcept C134018914 @default.
- W3031946210 hasConcept C142724271 @default.
- W3031946210 hasConcept C25498285 @default.
- W3031946210 hasConcept C2776914184 @default.
- W3031946210 hasConcept C2779830541 @default.
- W3031946210 hasConcept C2780114680 @default.
- W3031946210 hasConcept C2780415110 @default.
- W3031946210 hasConcept C42219234 @default.
- W3031946210 hasConcept C541997718 @default.
- W3031946210 hasConcept C71924100 @default.
- W3031946210 hasConceptScore W3031946210C126322002 @default.
- W3031946210 hasConceptScore W3031946210C134018914 @default.
- W3031946210 hasConceptScore W3031946210C142724271 @default.
- W3031946210 hasConceptScore W3031946210C25498285 @default.
- W3031946210 hasConceptScore W3031946210C2776914184 @default.
- W3031946210 hasConceptScore W3031946210C2779830541 @default.
- W3031946210 hasConceptScore W3031946210C2780114680 @default.
- W3031946210 hasConceptScore W3031946210C2780415110 @default.
- W3031946210 hasConceptScore W3031946210C42219234 @default.
- W3031946210 hasConceptScore W3031946210C541997718 @default.
- W3031946210 hasConceptScore W3031946210C71924100 @default.
- W3031946210 hasIssue "04" @default.
- W3031946210 hasLocation W30319462101 @default.
- W3031946210 hasOpenAccess W3031946210 @default.
- W3031946210 hasPrimaryLocation W30319462101 @default.
- W3031946210 hasRelatedWork W2261730256 @default.
- W3031946210 hasRelatedWork W2348468780 @default.
- W3031946210 hasRelatedWork W2355795571 @default.
- W3031946210 hasRelatedWork W2356926186 @default.
- W3031946210 hasRelatedWork W2364416014 @default.
- W3031946210 hasRelatedWork W2368722452 @default.
- W3031946210 hasRelatedWork W2372766257 @default.
- W3031946210 hasRelatedWork W2377074799 @default.
- W3031946210 hasRelatedWork W2377379140 @default.
- W3031946210 hasRelatedWork W2378058437 @default.
- W3031946210 hasRelatedWork W2378541704 @default.
- W3031946210 hasRelatedWork W2381264069 @default.
- W3031946210 hasRelatedWork W2389543959 @default.
- W3031946210 hasRelatedWork W2393529344 @default.
- W3031946210 hasRelatedWork W2590284324 @default.
- W3031946210 hasRelatedWork W2753640944 @default.
- W3031946210 hasRelatedWork W3029553359 @default.
- W3031946210 hasRelatedWork W3029735044 @default.
- W3031946210 hasRelatedWork W3031471590 @default.
- W3031946210 hasRelatedWork W3032586253 @default.
- W3031946210 hasVolume "30" @default.
- W3031946210 isParatext "false" @default.
- W3031946210 isRetracted "false" @default.
- W3031946210 magId "3031946210" @default.
- W3031946210 workType "article" @default.