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• W3031954709 abstract "Abstract Background The intestinal microbiota plays a crucial role in human health, which could affect host immunity and the susceptibility to infectious diseases. However, the role of intestinal microbiota in the immunopathology of invasive candidiasis remains unknown. Methods In this work, an antibiotic cocktail was used to eliminate the intestinal microbiota of conventional-housed (CNV) C57/BL6 mice, and then both antibiotic-treated (ABX) mice and CNV mice were intravenously infected with Candida albicans to investigate their differential responses to infection. Furthermore, fecal microbiota transplantation (FMT) was applied to ABX mice in order to assess its effects on host immunity against invasive candidiasis after restoring the intestinal microbiota, and 16S ribosomal RNA gene sequencing was conducted on fecal samples from both uninfected ABX and CNV group of mice to analyze their microbiomes. Results We found that ABX mice displayed significantly increased weight loss, mortality, and organ damage during invasive candidiasis when compared with CNV mice, which could be alleviated by FMT. In addition, the level of IL-17A in ABX mice was significantly lower than that in the CNV group during invasive candidiasis. Treatment with recombinant IL-17A could improve the survival of ABX mice during invasive candidiasis. Besides, the microbial diversity of ABX mice was significantly reduced, and the intestinal microbiota structure of ABX mice was significantly deviated from the CNV mice. Conclusions Our data revealed that intestinal microbiota plays a protective role in invasive candidiasis by enhancing IL-17A production in our model system." @default.
• W3031954709 created "2020-06-05" @default.
• W3031954709 creator A5002086817 @default.
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• W3031954709 date "2020-05-27" @default.
• W3031954709 modified "2023-10-01" @default.
• W3031954709 title "Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis" @default.
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• W3031954709 cites W1912289137 @default.
• W3031954709 cites W1960109612 @default.
• W3031954709 cites W1965368723 @default.
• W3031954709 cites W1976891952 @default.
• W3031954709 cites W1995586746 @default.
• W3031954709 cites W1998653357 @default.
• W3031954709 cites W2010679658 @default.
• W3031954709 cites W2024285987 @default.
• W3031954709 cites W2031701891 @default.
• W3031954709 cites W2037455811 @default.
• W3031954709 cites W2051572323 @default.
• W3031954709 cites W2060067993 @default.
• W3031954709 cites W2072970694 @default.
• W3031954709 cites W2080376010 @default.
• W3031954709 cites W2083102356 @default.
• W3031954709 cites W2107594154 @default.
• W3031954709 cites W2117727476 @default.
• W3031954709 cites W2133856765 @default.
• W3031954709 cites W2134985690 @default.
• W3031954709 cites W2145749857 @default.
• W3031954709 cites W2148103005 @default.
• W3031954709 cites W2162078360 @default.
• W3031954709 cites W2162965492 @default.
• W3031954709 cites W2165065263 @default.
• W3031954709 cites W2166171121 @default.
• W3031954709 cites W2170925079 @default.
• W3031954709 cites W2171016495 @default.
• W3031954709 cites W2175568660 @default.
• W3031954709 cites W2260819425 @default.
• W3031954709 cites W2298077113 @default.
• W3031954709 cites W2345390216 @default.
• W3031954709 cites W2346432479 @default.
• W3031954709 cites W2398894736 @default.
• W3031954709 cites W2422932714 @default.
• W3031954709 cites W2440084044 @default.
• W3031954709 cites W2468194934 @default.
• W3031954709 cites W2530691947 @default.
• W3031954709 cites W2547426852 @default.
• W3031954709 cites W2548846857 @default.
• W3031954709 cites W2548933161 @default.
• W3031954709 cites W2576197352 @default.
• W3031954709 cites W2587804829 @default.
• W3031954709 cites W2594112302 @default.
• W3031954709 cites W2595926651 @default.
• W3031954709 cites W2604209550 @default.
• W3031954709 cites W2624595700 @default.
• W3031954709 cites W2625068954 @default.
• W3031954709 cites W2626195186 @default.
• W3031954709 cites W2767888154 @default.
• W3031954709 cites W2768808834 @default.
• W3031954709 cites W2775583398 @default.
• W3031954709 cites W2782226838 @default.
• W3031954709 cites W2789495752 @default.
• W3031954709 cites W2795204891 @default.
• W3031954709 cites W2797443945 @default.
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• W3031954709 cites W2807195517 @default.
• W3031954709 cites W2808457437 @default.
• W3031954709 cites W2809439583 @default.
• W3031954709 cites W2815663922 @default.
• W3031954709 cites W2883201166 @default.
• W3031954709 cites W2902144712 @default.
• W3031954709 cites W2902927581 @default.
• W3031954709 cites W2912465744 @default.
• W3031954709 cites W2916590971 @default.
• W3031954709 cites W2917713377 @default.
• W3031954709 cites W2934588014 @default.
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• W3031954709 cites W2955323986 @default.
• W3031954709 cites W2965140029 @default.
• W3031954709 cites W2971602650 @default.
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• W3031954709 doi "https://doi.org/10.1186/s13054-020-02977-5" @default.
• W3031954709 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7251893" @default.
• W3031954709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32460890" @default.
• W3031954709 hasPublicationYear "2020" @default.
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