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- W3031955558 abstract "The results of chemotherapy in the treatment of advanced non-small-cell lung cancer (NSCLC)had reached a plateau.Targeted therapy is the key to improving efficacy.In the last 5 years the epidermal growth factor receptor(EGFR)has emerged as one of the most important targets for drug development in oncology.Small molecules that inhibit the tyrosine kinase(TK)domain of EGFR have become new critical weapons in the treatment of NSCLC.Monoclonal antibodies targeting the external domain of EGFR have been shown to have clinical benefit when combined with chemotherapy.Recent data suggest that multitargeted inhibitors might have greater activity owing to their ability to simultaneously block key signaling pathways.Preliminary results of such agents in clinical trials shows that they have a well-tolerated toxicity profile,and might have a promising value in the treatment of advanced non-small-cell lung cancer.Key words: Carcinoma,non-small-cell lung; Receptor,epidermal growth factor; Targeted therapy; Signal transduction" @default.
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- W3031955558 date "2008-05-28" @default.
- W3031955558 modified "2023-09-24" @default.
- W3031955558 title "Update on targeting EGFR in advanced non-small-cell lung cancer" @default.
- W3031955558 doi "https://doi.org/10.3760/cma.j.issn.1006-9801.2008.05.001" @default.
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