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- W3031971095 abstract "ObjectiveTo study the effects of active rewarming and passive rewarming on pulmonary oxidative stress and inflammatory response in rats with hypothermia induced by acute severe seawater immersion.MethodsSixty-four male healthy SD rats were randomly divided into the normal control group, the low temperature immersion group, the active rewarming group and the passive rewarming group. In accordance with rewarming time points, the two rewarming groups were further subdivided into the 2 h, 6 h and 12 h rewarming groups, each consisting of 8 animals. Effects of 2 different rewarming methods on lung oxygen free radicals (MDA, SOD, GSH-PX) and serum inflammatory factors (IL-6, IL-1β, TNF-a) were compared between the groups.Results(1) The MDA level [(2.84±0.46) nmol/mg pro] of the lungs in the 2 h active rewarming group was significantly higher than that of the 2 h passive rewarming group (P 0.05). The SOD activity in the lungs of the 12 h active rewarming group was higher than that of the 12 h passive rewarming group(P>0.05). (3) The GSH-PX activity in the lungs of the 2 h active rewarming group was slightly higher than that of the 2 h passive rewarming group(P>0.05). The GSH-PX activity in the lungs of the 6 h and 12 h active rewarming group was significantly higher than that of the 6 h and 12 h passive rewarming group(P<0.05). (4) The serum IL-1β and IL-6 levels of the 2 h passive rewarming group were obviously higher that those of the 2 h active rewarming group(P<0.05). The serum IL-1β and IL-6 levels in the 6 h and 12 h passive rewarming groups were slightly higher than those of the 6 h and 12 h active rewarming groups (P<0.05). (5) The serum TNF-a levels of the 2 h, 6 h and 12 h passive rewarming groups were slightly higher that those of the 2 h, 6 h and 12 h active rewarming groups(P<0.05).ConclusionAs compared with the active rewarming group, the activation of oxidative stress and inflammatory response in the passive rewarming group might worsen pulmonary lesion of the rats with hypothermia induced by acute severe seawater immersion.Key words: Rewarming; Hypothermia; Oxidative stress; Inflammatory factor; Rat" @default.
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- W3031971095 date "2018-10-28" @default.
- W3031971095 modified "2023-10-18" @default.
- W3031971095 title "Effects of two re-warming methods on oxidative stress and serum inflammatory factors in rats with hypothermia induced by acute severe seawater immersion" @default.
- W3031971095 doi "https://doi.org/10.3760/cma.j.issn.1009-6906.2018.05.003" @default.
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