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- W3031984325 abstract "ObjectiveTo study the difference spectrum of microRNAs(miRNAs,miR)expressions among lung cancer tissues,adjacent tissues and normal tissues and its correlation with the Tumor, Node and Metastasis(TNM)staging.MethodsAgilent miRNA expression microarray was used to detect nine cases of non-small cell lung cancer,adjacent tissues and normal tissues of the distal end.And then compare the expression profiles between different stages.ResultsWe screened out 36 differentially expressed miRNAs between adjacent tissues and cancer tissues,and 55 differentially expressed miRNAs between cancer tissues and normal tissues.Compared with distal normal tissues of patients with early stage lung cancer,distal normal tissues of patients withⅢa staging have 11 differentially expressed miRNAs,including hsa-miR-205, hsamiR-34b,et al.However,according to adjacent tissues, 11 differentially expressed miRNAs were screened between patients withⅠa andⅡa staging.According to cancer tissues, hsv2-miR-H7-3p and hsa-miR-23a* were differentially expressed amongⅠa,Ⅱa andⅢa stagings .Conclusion With the increasing of TNM staging,adjacent tissues and even distal tissues also occur on specific mircoRNA expression changes, which maybe suggest the ability of tumor invasion.Key words: Lung cancer; MicroRNA array; TNM staging" @default.
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- W3031984325 date "2015-02-08" @default.
- W3031984325 modified "2023-09-25" @default.
- W3031984325 title "Detection of differential microRNAexpression profilings among lung cancer,adjacent tissues and normal tissues" @default.
- W3031984325 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2015.02.070" @default.
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