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- W3032014562 abstract "ObjectiveTo evaluate the relationship between vitamin D receptor(VDR)(rs731236)single nucleotide polymorphisms and genetic susceptibility to overweight/obesity in school-age children of Han and Kazakh in Xinjiang Uygur Autonomous Region.MethodsThe VDR gene rs731236 genotypes were detected by using polymerase chain reaction-restriction fragment length polymorphism method in 250 overweight/obesity school-age children(127 Han, 123 Kazakh) and 255 healthy controls(131 Han, 124 Kazakh) as well.Results(1)There were statistically significant differences in the frequencies of rs731236 genotypes and alleles between the healthy controls of Han and Kazakh (χ2=9.904, P=0.005; χ2=9.312, P=0.002). (2)There were statistically significant differences in the frequencies of TT/Tt+ tt genotype and the alleles between the overweight/obesity cases and healthy controls of Kazakh(χ2=3.891, P=0.049; χ2=5.871, P=0.015). But the difference in frequencies of rs731236 genotypes and alleles between the overweight/obesity cases and controls of Han were not statistically significant(χ2=0.064, P=0.800; χ2=0.190, P=0.663). (3)There were statistically significant differences in the frequencies of TT/Tt+ tt genotype and alleles between the overweight/obesity cases and healthy controls of male school-age children of Kazakh (χ2=5.25, P=0.02; χ2=4.57, P=0.03), but the differences in frequencies of rs731236 genotypes and alleles between the overweight/obesity cases and controls were not statistically significant in female school-age children of Kazakh (χ2=0.06, P=0.80; χ2=1.40, P=0.24). There was no statistically significant difference in the frequencies of TT/Tt+ tt genotype and alleles between the overweight/obesity cases and healthy controls of female school-age children of Han(χ2=0.04, P=0.84; χ2=0.04, P=0.84), and there was no statistically significant difference in male school-age children of Han(χ2=0.05, P=0.82; χ2=0.18, P=0.67).ConclusionsVDR gene(rs731236)polymorphism bears ethnic diffe-rence.The polymorphisms of VDR gene polymorphism rs731236 are not associated with the susceptibility to overweight/obesity in school-age children of Han, while it is associated with the susceptibility to overweight/obesity school-age children in Kazakh, especially in male school-age children.Key words: Vitamin D receptor gene; Child; Overweight; Obesity; Kazakh; Han" @default.
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- W3032014562 date "2015-02-20" @default.
- W3032014562 modified "2023-09-24" @default.
- W3032014562 title "Association of the rs731236 polymorphism of vitamin D receptor gene in Han and Kazakh children with overweight/obesity" @default.
- W3032014562 doi "https://doi.org/10.3760/cma.j.issn.2095-428x.2015.04.015" @default.
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