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• W3032016101 abstract "ObjectiveTo investigate the efficacy and safety of mechanical thrombectomy for cardioembolic stroke (CES) due to atrial fibrillation.MethodsPatients with CES admitted to Nanjing First Hospital from January 2015 to September 2017 were enrolled retrospectively. They were divided into the thrombectomy group and the intravenous thrombolysis alone group. The baseline data, the National Institutes of Health Stroke Scale (NIHSS) score at 24 h after treatment, rates of good outcome (defined as the modified Rankin Scale score 0-2) at 90 d after onset, hemorrhagic transformation and death between the two groups were compared. Multivariate logistic regression analysis was used to determine the independent factors for the outcomes in patients with CES.ResultsA total of 117 patients with CES were enrolled, including 65 (55.6%) in the thrombectomy group and 52 (44.4%) in the intravenous thrombolysis alone group. Sixty-two patients (53.0%) had good outcome and 55 (47.0%) had poor outcome. The proportion of patients whose NIHSS score decreased >4 within 24 h after treatment (58.4% vs. 26.9%; χ2=6.254, P=0.007), rates of good recanalization (78.5% vs. 57.7%; χ2=5.850, P=0.016), and good outcome at 90 d (63.1%vs. 40.4%; χ2=5.972, P=0.015) in the thrombectomy group were significantly higher than those in the intravenous thrombolysis alone group, while there were no significant differences in the incidences of hemorrhagic transformation, symptomatic intracerebral hemorrhage and gastrointestinal bleeding, as well as mortality at 90 d. Multivariate logistic regression analysis showed that good recanalization (odds ratio [OR] 0.371, 95% confidence interval [CI] 0.157-0.876; P=0.024) and thrombectomy (OR 0.398, 95% CI 0.179-0.883; P=0.024) were the independent factors for good outcome, while diabetes (OR 6.572, 95% CI 1.684-25.641; P=0.007) was the independent factor for poor outcome.ConclusionThe efficacy of mechanical thrombectomy for patients with CES due to atrial fibrillation is superior to intravenous thrombolysis alone, and it dose not increase the mortality and complications. Good recanalization and mechanical thrombectomy are the independent factors for good outcome, while diabetes is an independent factor for poor outcome in patients with CES due to atrial fibrillation.Key words: Stroke; Brain Ischemia; Intracranial Embolism; Atrial Fibrillation; Thrombectomy; Endovascular Procedures; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome" @default.
• W3032016101 created "2020-06-05" @default.
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• W3032016101 date "2018-03-28" @default.
• W3032016101 modified "2023-09-24" @default.
• W3032016101 title "Efficacy and safety of mechanical thrombectomy for cardioembolic stroke due to atrial fibrillation: a comparison with intravenous thrombolysis alone" @default.
• W3032016101 doi "https://doi.org/10.3760/cma.j.issn.1673-4165.2018.03.001" @default.
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