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- W3032019907 abstract "ObjectiveTo explore the relationship of expression and the effect of preoperative radiotherapy of endothelin-1 (ET-1) and pyruvate kinase M-2 (PKM2) in rectal carcinoma.MethodsImmunohistochemical method was used to detect the expression of ET-1 and PKM2 proteins of rectal cancer tissues in 96 cases. The expressions of ET-1 and PKM2 were analyzed with the effect of preoperative radiotherapy in rectal cancer tissue.ResultsThe high expression of ET-1 protein was 59 cases (61.46%). The high expression of PKM2 proteins was 54 cases (56.25%). The high expressions of ET-1 and PKM2 protein were worsen the effect of tumor regressive grade (TRG) than lower expressions of those after preoperative radiotherapy of rectal cancer tissue (P<0.05). The protein expression of ET-1 and PKM2 were positively correlated (P=0.006).ConclusionsThe high expressed ET-1 and PKM2 proteins in rectal cancer are closely related to preoperative radiotherapy resistance. ET-1 and PKM2 proteins are expected to become new targets of radiotherapy sensitivity and radiotherapy sensitization of rectal cancer.Key words: Endothelin-1/ME; Pyruvate kinase/ME; Rectal neoplasms/RT/ME" @default.
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- W3032019907 date "2017-07-20" @default.
- W3032019907 modified "2023-10-07" @default.
- W3032019907 title "Expression and the effect of preoperative radiotherapy of ET-1 and PKM2 in rectal carcinoma" @default.
- W3032019907 doi "https://doi.org/10.3760/cma.j.issn.1008-1372.2017.07.013" @default.
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