Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032026545> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W3032026545 endingPage "303" @default.
- W3032026545 startingPage "299" @default.
- W3032026545 abstract "Objective To investigate the relationship of the age-related maculopathy susceptibility 2 (ARMS2) A69S polymorphism and polypoidal choroidal vasculopathy (PCV),and to explore the distribution of risk allele in PCV and exudative age-related macular degeneration (wAMD).Methods This is a systemic review and meta-analysis.A literature research was performed in Pubmed,Embase,Web of Knowledge,Chinese national Knowledge Infrastructure and Wanfang Medicine Database by the key words of ARMS2,LOC387715,A69S,rs10490924,age related macular degeneration,polypoidal choroidal vasculopathy,single nucleotide polymorphism.Case-control studies were included,while review,case report,or systemic reviews were excluded.The latest one of multiple articles was included only which published by the same group.The results of individual studies were pooled using the software Review Manager 5.1.4,and the correlation between allele frequencies,genotype and phenotype were analyzed.Results A total of 14 articles,consisting 2007 PCV patients,1308 wAMD patients and 3286 controls were recruited.The pooled odds ratio (OR) in random-effects models for genotype TT versus wild homozygous genotype GG is 5.20 (95％ CI:3.90-6.95).Heterozygous genotype GT mildly increased the risk in affecting PCV,and the OR of GT versus GG is 1.85 (95％ CI:1.42-2.40.The frequency of T allele in wAMD was higher than in PCV,pool OR=1.60 (95％CI:1.31-1.96).Conclusions The ARMS2 A69S variant is associated with PCV.Genotypes of TT and GT had an effect in increasing the risk of PCV,and the effect is even greater in genotype of TT.T allele had an effect in increasing the risk of PCV and wAMD,and the risk for wAMD is slightly greater than for PCV.Key words: Choroid diseases/etiology; Polymorphism,single nucleotide; Meta-analysis" @default.
- W3032026545 created "2020-06-05" @default.
- W3032026545 creator A5031164641 @default.
- W3032026545 creator A5081489339 @default.
- W3032026545 creator A5089710959 @default.
- W3032026545 date "2014-05-25" @default.
- W3032026545 modified "2023-09-23" @default.
- W3032026545 title "The age-related maculopathy susceptibility 2 polymorphism and polypoidal choroidal vasculopathy: a systemic review and meta-analysis" @default.
- W3032026545 doi "https://doi.org/10.3760/cma.j.issn.1005-1015.2014.03.017" @default.
- W3032026545 hasPublicationYear "2014" @default.
- W3032026545 type Work @default.
- W3032026545 sameAs 3032026545 @default.
- W3032026545 citedByCount "0" @default.
- W3032026545 crossrefType "journal-article" @default.
- W3032026545 hasAuthorship W3032026545A5031164641 @default.
- W3032026545 hasAuthorship W3032026545A5081489339 @default.
- W3032026545 hasAuthorship W3032026545A5089710959 @default.
- W3032026545 hasConcept C104317684 @default.
- W3032026545 hasConcept C118487528 @default.
- W3032026545 hasConcept C126322002 @default.
- W3032026545 hasConcept C134018914 @default.
- W3032026545 hasConcept C135763542 @default.
- W3032026545 hasConcept C143998085 @default.
- W3032026545 hasConcept C149737253 @default.
- W3032026545 hasConcept C153209595 @default.
- W3032026545 hasConcept C156957248 @default.
- W3032026545 hasConcept C180754005 @default.
- W3032026545 hasConcept C2776403814 @default.
- W3032026545 hasConcept C2778313320 @default.
- W3032026545 hasConcept C2781116099 @default.
- W3032026545 hasConcept C54355233 @default.
- W3032026545 hasConcept C555293320 @default.
- W3032026545 hasConcept C71924100 @default.
- W3032026545 hasConcept C86803240 @default.
- W3032026545 hasConcept C90924648 @default.
- W3032026545 hasConcept C95190672 @default.
- W3032026545 hasConceptScore W3032026545C104317684 @default.
- W3032026545 hasConceptScore W3032026545C118487528 @default.
- W3032026545 hasConceptScore W3032026545C126322002 @default.
- W3032026545 hasConceptScore W3032026545C134018914 @default.
- W3032026545 hasConceptScore W3032026545C135763542 @default.
- W3032026545 hasConceptScore W3032026545C143998085 @default.
- W3032026545 hasConceptScore W3032026545C149737253 @default.
- W3032026545 hasConceptScore W3032026545C153209595 @default.
- W3032026545 hasConceptScore W3032026545C156957248 @default.
- W3032026545 hasConceptScore W3032026545C180754005 @default.
- W3032026545 hasConceptScore W3032026545C2776403814 @default.
- W3032026545 hasConceptScore W3032026545C2778313320 @default.
- W3032026545 hasConceptScore W3032026545C2781116099 @default.
- W3032026545 hasConceptScore W3032026545C54355233 @default.
- W3032026545 hasConceptScore W3032026545C555293320 @default.
- W3032026545 hasConceptScore W3032026545C71924100 @default.
- W3032026545 hasConceptScore W3032026545C86803240 @default.
- W3032026545 hasConceptScore W3032026545C90924648 @default.
- W3032026545 hasConceptScore W3032026545C95190672 @default.
- W3032026545 hasIssue "03" @default.
- W3032026545 hasLocation W30320265451 @default.
- W3032026545 hasOpenAccess W3032026545 @default.
- W3032026545 hasPrimaryLocation W30320265451 @default.
- W3032026545 hasRelatedWork W1580751347 @default.
- W3032026545 hasRelatedWork W1830707906 @default.
- W3032026545 hasRelatedWork W1967583620 @default.
- W3032026545 hasRelatedWork W1970409240 @default.
- W3032026545 hasRelatedWork W1972840707 @default.
- W3032026545 hasRelatedWork W1991883543 @default.
- W3032026545 hasRelatedWork W2031743706 @default.
- W3032026545 hasRelatedWork W2036907245 @default.
- W3032026545 hasRelatedWork W2054361261 @default.
- W3032026545 hasRelatedWork W2054372560 @default.
- W3032026545 hasRelatedWork W2066476476 @default.
- W3032026545 hasRelatedWork W2075682565 @default.
- W3032026545 hasRelatedWork W2077045977 @default.
- W3032026545 hasRelatedWork W2167130628 @default.
- W3032026545 hasRelatedWork W2169386178 @default.
- W3032026545 hasRelatedWork W2580151107 @default.
- W3032026545 hasRelatedWork W2784304445 @default.
- W3032026545 hasRelatedWork W3004420668 @default.
- W3032026545 hasRelatedWork W3010291272 @default.
- W3032026545 hasRelatedWork W2559703549 @default.
- W3032026545 hasVolume "30" @default.
- W3032026545 isParatext "false" @default.
- W3032026545 isRetracted "false" @default.
- W3032026545 magId "3032026545" @default.
- W3032026545 workType "article" @default.