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- W3032037270 abstract "miR-106b-25 cluster is composed of miR-106b,miR-93 and miR-25,and is a paralogue of miR-17-92 cluster.Some studies have shown that the members in miR-106b-25 cluster abundantly expressed in many cancers.Over-expressions of these miRNAs promote the growth of tumor cells by negatively regulating p21 and p57,and suppress the apoptosis of tumor cells through inhibition of Bim.Moreover,high expression of miR-106b-25 cluster might endue tumor cells with resistance to inhibitory effect of cell growth induced by TGF-β signaling.Key words: Neoplasms; Transforming growth factor beta; Signal transduction; miR-106b-25 cluster" @default.
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- W3032037270 date "2011-03-08" @default.
- W3032037270 modified "2023-09-23" @default.
- W3032037270 title "Advances in study of miR-106b-25 cluster in cancer" @default.
- W3032037270 doi "https://doi.org/10.3760/cma.j.issn.1673-422x.2011.03.001" @default.
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