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- W3032049255 abstract "目的 探讨趋化因子受体 CCR7的表达对预测胃癌淋巴结转移的临床价值.方法对 132例行胃癌根治术和 30例内镜活检的胃癌组织标本采用免疫组化法检测 CCR7的表达.结果 CCR7在 56.8%的病例中呈阳性表达.CCR7在伴有淋巴结转移病例中的表达显著高于无淋巴结转移者 (P< 0.001);其与肿瘤大小( P< 0.01)、浸润深度( P< 0.001)、淋巴管浸润( P< 0.001)和 TNM分期( P< 0.001)相关,并与多层螺旋 CT( MSCT)和病理检查判断的淋巴结转移密切相关( P< 0.05,P< 0.01);但与年龄、性别、肿瘤位置、 Lauren分类和血管浸润无关.在回顾性研究中,CCR7表达对胃癌淋巴结转移判断的敏感性、特异性、阳性预测值( PPV)、阴性预测值( NPV)和准确率分别为 83.1%、 73.8%、 78.7%、 78.9%和 78.8%;在前瞻性研究中,CCR7表达对胃癌淋巴结转移判断的敏感性、特异性、 PPV、 NPV和准确率分别达 85.0%、 60.0%、 80.9%、 66.7%和 76.7%.结论 CCR7表达与胃癌淋巴结转移密切相关,对内镜活检组织检测 CCR7的表达有助于预测胃癌淋巴结转移及决定淋巴结清扫的手术范围.CCR7可能成为胃癌治疗的新靶点。" @default.
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- W3032049255 date "2004-07-15" @default.
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- W3032049255 title "Expression of chemokine receptor CCR7 and its association with lymph node metastasis in gastric carcinoma" @default.
- W3032049255 doi "https://doi.org/10.3760/cma.j.issn.1671-0274.2004.04.022" @default.
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