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- W3032055229 abstract "：Objective To examine therelationship and its clinical significance between hepatitis B virus (HBV) DNA level andthe degree of liver fibrosis in patients with hepatitis B liver cirrhosis. Methods A totalof 263 hospitalized patients with type B hepatitis and liver cirrhosis, registered to ourdepartment between 2004 and 2006, were investigated retrospectively. All the patientsunderwent Child- Pugh classification of liver function, tests of HBV DNA, serum HBVmarkers, hyaluronic acid (HA), human type Ⅲprocollagen(Hpc- Ⅲ ), type Ⅳ collagen ( Ⅳ -C) and laminin (LN),besides, abdominal ultrasound scanning was performed to measure the size of spleen,internal diameters of portal vein and splenic vein.Gastroscopy was used for evaluatingesophageal varices, and common complications were recorded. The patients were divided intofour groups according to HBV DNA levels, HBV DNA ＜ 103 copies/ml (G1), HBV DNA 103 to＜105 copies/ml(G2), HBV DNA 105 to＜ 107 copies/ml (G3) and HBV DNA≥ 107 copies/ml (G4). Differences in Child-Pugh classification, serummarkers of liver fibrosis and portal hypertension index between groups were compared, andso were common complications of liver cirrhosis in each group.Results Out of 263 cases,217(82.5%) were with positive HBV DNA. There were no statistical differences in Child-Pughclassification, HA, Hpc-Ⅲ, Ⅳ-Cor LN among patients with various HBV DNA levels (all P＞0.05), nor in spleen size,internal diameters of portal vein and splenic vein, degree of esophageal varices among thefour groups (all P＞0.05). The incidences of complications such asgastrointestinal bleeding,secondary infection, ascites, hepatic encephalopathy and livercancer did not differ among the four groups either (all P＞0.05). Conclusion While HBV DNA in most hepatitis Bpatients with cirrhosis are positive,there is no obvious correlation between serum HBV DNAlevel and severity of cirrhosis or incidence of complications.Key words: Hepatitis B; Liver cirrhosis; Fibrosis,liver; Complications; DNA Viral" @default.
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- W3032055229 date "2010-06-15" @default.
- W3032055229 modified "2023-09-24" @default.
- W3032055229 title "Relationship between HBVDNA level and degree of liver fibrosis in hepatitis B patients with cirrhosis" @default.
- W3032055229 doi "https://doi.org/10.3760/cma.j.issn.1674-1927.2010.03.009" @default.
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