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- W3032062016 abstract "ObjectiveTo evaluate the value of quantitative analysis of dynamic contrast-enhanced MRI (DCE-MRI) and diffusion weighted imaging (DWI) for differentiating malignant from benign orbital lymphoproliferative disorder (OLPD).MethodsForty-three patients with OLPDs (20 patients with benign OLPDs and 23 patients with orbital lymphoma) confirmed by histopathology or clinical follow-up were enrolled in this retrospective study. Quantitative parameters of DCE-MRI including volume transfer constant (Ktrans), flux rate constant (Kep), and extravascular extracellular volume fraction (Ve) and mean apparent diffusion coefficient (ADC) values were obtained. χ2 test and t test were used to compare the differences of qualitative and quantitative parameters between two groups. Receiver operating characteristic (ROC) curve analyses were used to evaluate the diagnostic ability of each parameter and its combination.ResultsMalignant group showed significantly lower mean ADC values and higher Kep values than benign group [ADC: (0.674±0.126) ×10-3 mm2/s vs (1.030±0.304) ×10-3 mm2/s, P<0.001;Kep: (1.299±0.566)/min vs (0.787±0.311)/min, P= 0.001], while no significant differences was found on Ktrans (P= 0.637) and Ve (P= 0.023). ROC analyses results indicated that, a sensitivity of 95.7%, specificity of 80.0% and area under curve (AUC) of 0.896 could be obtained, when using ADC= 0.809 ×10-3 mm2/s as the cut-off value. Setting the Kep value of0.863/min as the cut-off value, a sensitivity of 91.3%, specificity of 75.0% and AUC of 0.848 could be obtained. When combination of mean ADC and Kep was used, optimal diagnostic performance could be obtained (AUC, 0.926;sensitivity, 91.3%;specificity, 90.0%).ConclusionMean ADC values and Kep are significant variables in predicting malignant OLPDs. Combination of DWI and DCE-MRI can further improve the diagnostic capability in differentiating malignant from benign OLPDs.Key words: Orbit; Lymphoma; Lymphoproliferative disorders; Diffusion magnetic resonance imaging; Dynamic contrast-enhanced" @default.
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- W3032062016 date "2018-02-10" @default.
- W3032062016 modified "2023-09-25" @default.
- W3032062016 title "Quantitative analysis of dynamic contrast-enhanced MRI in conjunction with diffusion weighted imaging for differentiating benign and malignant orbital lymphoproliferative disorder" @default.
- W3032062016 doi "https://doi.org/10.3760/cma.j.issn.1005-1201.2018.02.003" @default.
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