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- W3032072163 abstract "CUE domain-containing protein 2 (CUEDC2), a newly discovered CUE domain containing protein, plays an important role in the regulation of cell cycle, oncogenesis, inflammatory and stress response. Researches demonstrate that CUEDC2 has a closely relationship with the progression and drug resistance of leukemia through mediating the protein degradation. CUEDC2 involves in the development of leukemia and solid tumors via leading to the spindle assemble checkpoint (SAC) inactivation and chromosomal instability. However, it is still controversial whether CUEDC2 acts as a oncogene or a cancer inhibitor in the initiation and progression of the leukemia and the solid tumors. In this review, we will summarize the multi-functions of CUEDC2 in the initiation and progression of the leukemia and solid tumors.Key words: CUE domain containing protein 2; Leukemia; NF-kappa B; Janus kinases; Suppressor of cytokine signaling proteins" @default.
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- W3032072163 date "2015-05-20" @default.
- W3032072163 modified "2023-09-27" @default.
- W3032072163 title "Research progress of action mechanism of CUE domain-containing protein 2 on the initiation and progression of leukemia and solid tumors" @default.
- W3032072163 doi "https://doi.org/10.3760/cma.j.issn.1673-419x.2015.03.012" @default.
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