FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032084875> ?p ?o ?g. }

• W3032084875 endingPage "425" @default.
• W3032084875 startingPage "419" @default.
• W3032084875 abstract "Objective To observe and compare the changes of bone mass and microarchitecture in ovariectomized rat left tibia by dual energy X-ray absorptiometry(DXA)and microCT(μCT).Methods Forty seven-month-old SD rats were randomly divided into ovariectomized(OVX)and sham-operated(SHAM)groups,twenty in each group.After killed at 3 weeks and 15 weeks post-surgery,DXA scanning were performed in the left tibia in vitro.The images of left tibia were divided into seven isometric regions of interest(ROI1-7).When analysis finished,bone density(BD)of each ROI and the total bone were determined.The samples were fixed by 4% paraformaldehyde and then placed in the specimen holder filled with deionized water.The sensitive regions for bone mass changes were selected for scanning by Fluro.After scanning,the regions involving 0.4mm slice thickness and 2.5mm distance far end from tibial growth plate were selected as the ROI of cortical bone analysis.The regions selected as ROI of cancellous analysis,were involved in 1.2mm slice thickness and 0.7mm distance at the far end from tibial growth plate.After three dimension reconstruction.2D images of the maximum intensity projection and pictures of 3D microarchitecture were obtained.and BD and microarchitectural parameters were quantitatively identified.All data was statistically processed with SPSS for Windows.Results At the 3rd week,BD of ROI1 in rat left tibia in OVX(0.2346±0.0280)g/cm2 was much lower than that(0.2660±0.01990)g/cm2 in SHAM(P＜0.05).While at the 15th week,BD of ROI1(0.2527±0.0161)and ROI2(0.1862±0.0052)g/cm2 in OVX were both lower than SHAM(0.2793±0.0229)and(0.1986±0.0102)g/cm2 respectively,P＜0.01 for both).Compared wim SHAM rat[cortical area(Ct-Ar)=(0.3138±0.0621)mm2,marrow area(Ma-Ar)=(8.44±1.25)mm2,total area(T-Ar)=(8.75±1.26)mm2,moment of inertia(Mm)=(3.485±0.373)mm4],there were significant increases in Ct-Ar(0.4306±0.1308)mm2,Ma-Ar(10.31±1.98)mm2,T-Ar(10.74±2.05)mm2,and Mm(4.101±0.726)mm4 in OVX mice at the 3rd week(P＜0.05 for all).While at the 15th week,only cortical thickness(Ct-Th)(0.0235±0.0024)mm showed a decrease in OVX group(P＜0.05).In OVX group,Ct-Th(0.0235±0.0024)mm and Ct-Ar(0.2528±0.0367)mm at 15 weeks were lower than that[Ct-Th=(0.0377±0.0098)mm,Ct-Ar=(0.4306±0.1308)mm2 at 3 weeks(P＜0.01 for both)].In SHAM group,inner perimeter(In-Pm)(13.38±0.54)mm,outer perimeter(Ot-Pm)(13.59±0.56)mm and Mm(4.096±0.364)mm4 at 15 weeks were higher than that[In-Pm=(12.41±0.74)mm,Ot-Pm=(12.63±0.75)mm,Mm=(3.485±0.373)mm4 at 3 weeks(P＜0.01 for all)].OVX rats had much lower volume BD(vBD)(288.2±48.2)mg/mm3,tissue BD(tBD)(604.5±45.3)mg/mm3,bone volume fraction(BVF)(25.1±5.1)%,and trabecular mumeer(Tb-N)(6.04±2.94)mm-1(P＜0.01 for all),but higher structure model index(SMI)3.09±0.27 and trabecular separation(Tb-Sp)(0.186±0.129)mm than SHAM 2.63±0.21 and(0.078±0.038)mm respectively at the 3rd week(P＜0.01 and P＜0.05 respectively).At the 15th week,vBD(271.2±50.9)mg/mm3,BVF(21.6±5.2)%and Tb-N (3.21±1.92)mm-1 in OVX were still lower than SHAM[vBD=(389.8±77.0)mg/mm3,BVF=(30.9±6.0)%,Tb-N=(7.44±3.53)mm-1 respectively(P＜0.01 for all)],SMI 3.11±0.36 and Tb-Sp(0.370±0.215)mm in OVX were also higher than SHAM 2.58±0.36 and(0.141±0.104)mm(P＜0.01 for both),but no significant difference of tBD could be found.In OVX group.the scores of tBD(691.0±36.7)mg/mm,Tb-Th(0.040±0.009)mm,Tb-N(3.21±1.92)mm-1,Tb-Sp(0.370±0.215)mm in the 15th week were higher than that[tBD=(604.5±45.3)mg/mm,Tb-Th=(0.030±0.002)mm,Tb-N=(6.04±2.94)mm-1,Tb-Sp=(0.186±0.129)mm respectively]in the 3rd week (P＜0.05 for all),while there were no differences between the 3rd and the 15th week in SHAM group.Conclusions DXA is weak in detecting the tiny changes of BD though it is convenient and non-invasive.μCT is suitable to detect the changes of bone mass and microarchitecture.Key words: X-rays;  Bone density; Tomography,X-ray computed" @default.
• W3032084875 created "2020-06-05" @default.
• W3032084875 creator A5006230838 @default.
• W3032084875 creator A5007146453 @default.
• W3032084875 creator A5015414010 @default.
• W3032084875 creator A5061540866 @default.
• W3032084875 creator A5062604514 @default.
• W3032084875 creator A5083506223 @default.
• W3032084875 date "2008-04-10" @default.
• W3032084875 modified "2023-09-23" @default.
• W3032084875 title "The analysis of bone mass and microarchitecture in ovariectomized rat by dual energy X-ray absorptiometry and microCT" @default.
• W3032084875 doi "https://doi.org/10.3321/j.issn:1005-1201.2008.04.018" @default.
• W3032084875 hasPublicationYear "2008" @default.
• W3032084875 type Work @default.
• W3032084875 sameAs 3032084875 @default.
• W3032084875 citedByCount "0" @default.
• W3032084875 crossrefType "journal-article" @default.
• W3032084875 hasAuthorship W3032084875A5006230838 @default.
• W3032084875 hasAuthorship W3032084875A5007146453 @default.
• W3032084875 hasAuthorship W3032084875A5015414010 @default.
• W3032084875 hasAuthorship W3032084875A5061540866 @default.
• W3032084875 hasAuthorship W3032084875A5062604514 @default.
• W3032084875 hasAuthorship W3032084875A5083506223 @default.
• W3032084875 hasConcept C105702510 @default.
• W3032084875 hasConcept C126322002 @default.
• W3032084875 hasConcept C126838900 @default.
• W3032084875 hasConcept C142724271 @default.
• W3032084875 hasConcept C2776350087 @default.
• W3032084875 hasConcept C2776541429 @default.
• W3032084875 hasConcept C2776886416 @default.
• W3032084875 hasConcept C2777164284 @default.
• W3032084875 hasConcept C2777236700 @default.
• W3032084875 hasConcept C2781440623 @default.
• W3032084875 hasConcept C2989005 @default.
• W3032084875 hasConcept C36454342 @default.
• W3032084875 hasConcept C63565114 @default.
• W3032084875 hasConcept C71924100 @default.
• W3032084875 hasConcept C8264082 @default.
• W3032084875 hasConceptScore W3032084875C105702510 @default.
• W3032084875 hasConceptScore W3032084875C126322002 @default.
• W3032084875 hasConceptScore W3032084875C126838900 @default.
• W3032084875 hasConceptScore W3032084875C142724271 @default.
• W3032084875 hasConceptScore W3032084875C2776350087 @default.
• W3032084875 hasConceptScore W3032084875C2776541429 @default.
• W3032084875 hasConceptScore W3032084875C2776886416 @default.
• W3032084875 hasConceptScore W3032084875C2777164284 @default.
• W3032084875 hasConceptScore W3032084875C2777236700 @default.
• W3032084875 hasConceptScore W3032084875C2781440623 @default.
• W3032084875 hasConceptScore W3032084875C2989005 @default.
• W3032084875 hasConceptScore W3032084875C36454342 @default.
• W3032084875 hasConceptScore W3032084875C63565114 @default.
• W3032084875 hasConceptScore W3032084875C71924100 @default.
• W3032084875 hasConceptScore W3032084875C8264082 @default.
• W3032084875 hasIssue "04" @default.
• W3032084875 hasLocation W30320848751 @default.
• W3032084875 hasOpenAccess W3032084875 @default.
• W3032084875 hasPrimaryLocation W30320848751 @default.
• W3032084875 hasRelatedWork W2325189043 @default.
• W3032084875 hasRelatedWork W2335148786 @default.
• W3032084875 hasRelatedWork W2352162588 @default.
• W3032084875 hasRelatedWork W2361225619 @default.
• W3032084875 hasRelatedWork W2370182748 @default.
• W3032084875 hasRelatedWork W2372466000 @default.
• W3032084875 hasRelatedWork W2376891295 @default.
• W3032084875 hasRelatedWork W2389211944 @default.
• W3032084875 hasRelatedWork W2394423707 @default.
• W3032084875 hasRelatedWork W2415974710 @default.
• W3032084875 hasRelatedWork W2766823300 @default.
• W3032084875 hasRelatedWork W2806312023 @default.
• W3032084875 hasRelatedWork W2810934859 @default.
• W3032084875 hasRelatedWork W2956132051 @default.
• W3032084875 hasRelatedWork W2996911945 @default.
• W3032084875 hasRelatedWork W3029827096 @default.
• W3032084875 hasRelatedWork W3030317191 @default.
• W3032084875 hasRelatedWork W3032849016 @default.
• W3032084875 hasRelatedWork W3207625235 @default.
• W3032084875 hasRelatedWork W2342222345 @default.
• W3032084875 hasVolume "42" @default.
• W3032084875 isParatext "false" @default.
• W3032084875 isRetracted "false" @default.
• W3032084875 magId "3032084875" @default.
• W3032084875 workType "article" @default.