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- W3032086571 abstract "ObjectiveDespite the fact that microRNA (miRNA, miR)-338-3p can play an important role in many kinds of tumors, whether it has an influence on liver cancer (LC) is undetermined.MethodsIn this study, the expression of miR 338-3p in human LC tissues and cells was determined by real-time quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR) assay. The effect of miR-338-3p on LC cell growth was determined by cell counting kit-8 (CCK-8) and colony formation assay. Bioinformatic analysis, luciferase reporter assays and western blotting were used to determine the target of miR-338-3p.ResultsThe expression of miR-338-3p was decreased in LC cells as well as tissues(1.37±0.05, 0.95±0.03, 1.15±0.09 vs. 3.38±0.11, t=5.235, P=0.019; 0.89±0.08 vs. 2.03±0.05, t=3.535, P=0.008). Clone formation and cell proliferation are suppressed by enhanced expression of miR-338-3p in LC cells. Moreover, we found that miR-338-3p targeted sphingosine kinase 2 (SphK2). The silencing of SphK2 showed the identical influence to overexpression of miR-338-3p in LC cells. Overexpression of SphK2 without 3’ untranslated region remarkably enhanced the growth suppression triggered by miR-338-3p in LC cells.ConclusionmiR-338-3p could influence the development of LC through targeting SphK2, suggesting miR-338-3p could serve as an innovative therapeutic strategy in terms of LC.Key words: Liver cancer; Proliferation; MicroRNA-338-3p; Sphingosine kinase 2" @default.
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- W3032086571 date "2018-11-08" @default.
- W3032086571 modified "2023-09-23" @default.
- W3032086571 title "MicroRNA-338-3p suppresses proliferation of human liver cancer cells by targeting sphingosine kinase 2" @default.
- W3032086571 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2018.11.025" @default.
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