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- W3032089923 abstract "ObjectiveTo investigate the influence of clinicopathological characteristics, endostain and epithelial growth factor receptor(EGFR) on the survival of the perioperative non-small cell lung cancer(NSCLC).MethodsFifty patients with NSCLC undergoing surgical treatment in the Department of Cardiothoracic Surgery in Shanghai Sixth People’s Hospital affiliated to Shanghai Jiao Tong University between January 2008 and December 2008 were collected, and were followed up after surgery till January 2014, with the mean time of follow-up of 36.44 months. The survival-related factors for these 50 patients with NSCLC were analyzed using multivariate regression analysis.ResultsThe 5-year survival was 53.7%, and the median survival time was 50.6 months for these 50 patients with NSCLC. The survival in patients with tumor maximum dimmer <3.5 cm was significantly bigger than that in those with tumor maximum dimmer ≥3.5 cm(χ2=8.086, P=0.004). The survival in patients with adenocarcinoma was significantly bigger than that in those with squamous carcinoma(χ2=7.527, P=0.006). The survival in patients with stage Ⅰ NSCLC was significantly bigger than those in patients with stage Ⅱ and stage Ⅲ NSCLC(χ2=4.681, P =0.03; χ2=7.990, P=0.005). The survival in patients with endostatin <20.4 ng/mL before operation was significantly bigger than that in those with endostatin≥20.4 ng/mL before operation(χ2=5.213, P=0.022). The survival in patients with EGFR ≥44.7 pg/mL after operation was significantly bigger than that in those with EGFR<44.7 pg/mL after operation (χ2=13.908, P=0.000). Multivariate regression analysis indicated that EGFR after operation was an independent prognostic factor(P=0.000).ConclusionThe patients with low level of endostain before operation and high level of EGFR after operation may gain better survival.Key words: Non-small cell lung, cancer; Endostain; Epithelial growth factor receptor; Survival rate; Prognosis; Follow-up studies" @default.
- W3032089923 created "2020-06-05" @default.
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- W3032089923 date "2015-05-28" @default.
- W3032089923 modified "2023-09-23" @default.
- W3032089923 title "Influence of endostain and epithelial growth factor receptor on the survival of the perioperative no-small cell lung cancer" @default.
- W3032089923 doi "https://doi.org/10.3877/cma.j.issn.2095-8773.2015.02.005" @default.
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