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- W3032092009 abstract "Objective To observe the effect of lipoprostaglandin E1 (lipo-PegE1) with Chinese rhubarb in treatment of patients with hepatorenal syndrome.Methods 26 hepatorenal syndrome patients were divided into two groups randomly.Based on the comprehensive treatment,treatment group(24 cases)were given lipo-PegE1 with Chinese rhubarb,while control group(22 cases)were given dopamine and large-dose of furosemide.The clinical effect,total urine output,BUN,creatinine,liver function,blood ammonia and prognosis were observed.Results The total effective rate was 85.71％ in treatment group,and were significantly better than the rate(41.67％ )in control group( x2 =0.02,P ＜0.01 ).In treatment group,urine output were significantly increased after the treatment ( t =8.98,P ＜ 0.01).BUN and serum creatinine were significantly lower( t =8.53,17.22,P ＜ 0.01),ALT and TBil improved in different degree and blood ammonia decreased ( t =15.99,4.56,9.22,P ＜ 0.01 ) ; while in control group,these parameters had no significant improvement.After treatment,there were significant differences in creatinine,BUN,ALT,TBil and ammonia between the two groups( t =10.72,8.96,5.86,2.35,9.01,P ＜ 0.05).Conclusions Lipo-PegE1 can change hemodynamics and increase the urine output,while Chinese rhubarb can reduce endotoxin in patients with hepatorenal syndrome,so lipo-PegEl combine with Chinese rhubarb can get enhanced results in the treatment of hepatorenal syndrome.Key words: Hepatorenal syndrome; Liver cirrhosis; Lipoprostaglandin E1; Chinese rhubarb" @default.
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- W3032092009 date "2011-10-25" @default.
- W3032092009 modified "2023-09-27" @default.
- W3032092009 title "Effect of lipoprostaglandin E1 combined with Chinese rhubarb in treating hepatorenal syndrome" @default.
- W3032092009 doi "https://doi.org/10.3760/cma.j.issn.1673-4149.2011.05.005" @default.
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