Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032103532> ?p ?o ?g. }
- W3032103532 endingPage "20082" @default.
- W3032103532 startingPage "20073" @default.
- W3032103532 abstract "The Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) is a key enzyme in pathways regulating tumor growth signaling, and recently gained interest as a promising anticancer drug target. Many SHP2 inhibitors are currently under development, including SHP099, which has shown potent anticancer activity at low concentrations in vivo. In this work, we developed multilayer coatings for localized delivery of SHP099 to improve upon current cancer therapies. Layer-by-layer self-assembly was used to develop films composed of chitosan and poly-carboxymethyl-β-cyclodextrin (PβCD) for the delivery of SHP099. SHP099 was successfully loaded into multilayer films via host-guest interactions with PβCD. Nuclear magnetic resonance spectroscopy confirmed the occurrence of this supramolecular assembly by identifying the interaction of specific terminal SHP099 protons with the protons of the CD. SHP099 release from assembled films was detected over 96 hours, and was found to inhibit colony formation of human breast adenocarcinoma cells in vitro. These multilayer films have the potential to be used in a range of anticancer applications and overcome common complications of systemic chemotherapeutic administration, while maximizing SHP099 efficacy." @default.
- W3032103532 created "2020-06-05" @default.
- W3032103532 creator A5008419048 @default.
- W3032103532 creator A5011515634 @default.
- W3032103532 creator A5019819720 @default.
- W3032103532 creator A5022646522 @default.
- W3032103532 creator A5027144540 @default.
- W3032103532 creator A5050808980 @default.
- W3032103532 creator A5054761552 @default.
- W3032103532 creator A5071869928 @default.
- W3032103532 date "2020-01-01" @default.
- W3032103532 modified "2023-09-23" @default.
- W3032103532 title "Controlled delivery of a protein tyrosine phosphatase inhibitor, SHP099, using cyclodextrin-mediated host–guest interactions in polyelectrolyte multilayer films for cancer therapy" @default.
- W3032103532 cites W1674292201 @default.
- W3032103532 cites W1965642226 @default.
- W3032103532 cites W1966136237 @default.
- W3032103532 cites W1973682062 @default.
- W3032103532 cites W1975207418 @default.
- W3032103532 cites W1979491885 @default.
- W3032103532 cites W1990486870 @default.
- W3032103532 cites W2003288421 @default.
- W3032103532 cites W2007879684 @default.
- W3032103532 cites W2010481935 @default.
- W3032103532 cites W2017606424 @default.
- W3032103532 cites W2020999936 @default.
- W3032103532 cites W2027147390 @default.
- W3032103532 cites W2031281559 @default.
- W3032103532 cites W2035170064 @default.
- W3032103532 cites W2036058899 @default.
- W3032103532 cites W2042324535 @default.
- W3032103532 cites W2047101821 @default.
- W3032103532 cites W2048878719 @default.
- W3032103532 cites W2058351664 @default.
- W3032103532 cites W2094847571 @default.
- W3032103532 cites W2100003552 @default.
- W3032103532 cites W2106315777 @default.
- W3032103532 cites W2149107062 @default.
- W3032103532 cites W2153566962 @default.
- W3032103532 cites W2277921049 @default.
- W3032103532 cites W2303068520 @default.
- W3032103532 cites W2315318935 @default.
- W3032103532 cites W2333975681 @default.
- W3032103532 cites W2410419349 @default.
- W3032103532 cites W2417365924 @default.
- W3032103532 cites W2468923062 @default.
- W3032103532 cites W2475259576 @default.
- W3032103532 cites W2514254670 @default.
- W3032103532 cites W2519075885 @default.
- W3032103532 cites W2557857134 @default.
- W3032103532 cites W2751912697 @default.
- W3032103532 cites W2781625157 @default.
- W3032103532 cites W2790214250 @default.
- W3032103532 cites W2891517856 @default.
- W3032103532 cites W2912278480 @default.
- W3032103532 cites W2913986569 @default.
- W3032103532 cites W2920100416 @default.
- W3032103532 cites W2925089528 @default.
- W3032103532 cites W3007462659 @default.
- W3032103532 cites W332934928 @default.
- W3032103532 doi "https://doi.org/10.1039/d0ra03864d" @default.
- W3032103532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35520441" @default.
- W3032103532 hasPublicationYear "2020" @default.
- W3032103532 type Work @default.
- W3032103532 sameAs 3032103532 @default.
- W3032103532 citedByCount "6" @default.
- W3032103532 countsByYear W30321035322020 @default.
- W3032103532 countsByYear W30321035322021 @default.
- W3032103532 countsByYear W30321035322022 @default.
- W3032103532 crossrefType "journal-article" @default.
- W3032103532 hasAuthorship W3032103532A5008419048 @default.
- W3032103532 hasAuthorship W3032103532A5011515634 @default.
- W3032103532 hasAuthorship W3032103532A5019819720 @default.
- W3032103532 hasAuthorship W3032103532A5022646522 @default.
- W3032103532 hasAuthorship W3032103532A5027144540 @default.
- W3032103532 hasAuthorship W3032103532A5050808980 @default.
- W3032103532 hasAuthorship W3032103532A5054761552 @default.
- W3032103532 hasAuthorship W3032103532A5071869928 @default.
- W3032103532 hasBestOaLocation W30321035321 @default.
- W3032103532 hasConcept C108636557 @default.
- W3032103532 hasConcept C115624301 @default.
- W3032103532 hasConcept C11960822 @default.
- W3032103532 hasConcept C121608353 @default.
- W3032103532 hasConcept C12554922 @default.
- W3032103532 hasConcept C150903083 @default.
- W3032103532 hasConcept C171250308 @default.
- W3032103532 hasConcept C185592680 @default.
- W3032103532 hasConcept C192562407 @default.
- W3032103532 hasConcept C202751555 @default.
- W3032103532 hasConcept C207001950 @default.
- W3032103532 hasConcept C2776165026 @default.
- W3032103532 hasConcept C2779433975 @default.
- W3032103532 hasConcept C2779820397 @default.
- W3032103532 hasConcept C2983331546 @default.
- W3032103532 hasConcept C54355233 @default.
- W3032103532 hasConcept C55493867 @default.
- W3032103532 hasConcept C8010536 @default.
- W3032103532 hasConcept C85528070 @default.
- W3032103532 hasConcept C86803240 @default.