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- W3032109846 abstract "ObjectiveTo explore the relationship between blood lipid levels and cerebrovascular hemodynamic indices (CVHI) in a young and middle-aged population, and to identify reference values for early warning of stroke.MethodBetween June 2015 and June 2016, a total of 6 252 young and middle-aged patients were assessed for cerebrovascular function in The Health Management Center of Affiliated Hospital of Guizhou Medical University. Patients were divided into abnormal and normal blood lipid groups. Differences in CVHI indicators and scores between the groups were determined, and factors influencing CVHI indices were compared using multivariate logistic regression analysis.ResultsMean (Vmean), maximum (Vmax), and minimum blood flow velocity (Vmin) and cumulative scores for CVHI indices in the abnormal blood lipid group were significantly lower than in the normal blood lipid group (P<0.001). However, pulse wave velocity, characteristic impedance, peripheral vascular resistance, dynamic resistance, critical pressure, and differences between diastolic blood pressure and critical pressure were greater than those in the normal blood lipid group (P<0.001). Multivariate logistic regression analysis indicated that a high triglyceride level, overweight or obesity, high systolic blood pressure, high diastolic blood pressure, and age were risk factors for low CVHI scores, with odds ratios (95% confidence intervals) of 1.455 (1.195-1.771), 2.271 (1.782-2.895), 5.967 (4.557-7.815), 4.251 (3.349-5.396), 2.560 (1.993-3.287), and 1.448 (1.189-1.763).ConclusionAbnormal blood lipid levels can lead to abnormal cerebrovascular function in young and middle-aged population; elevated triglyceride level was an independent risk factor for impaired cerebrovascular function.Key words: Young and middle-aged; Dyslipidemia; Cerebral blood flow dynamics; Cerebrovascular disease" @default.
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- W3032109846 date "2018-10-20" @default.
- W3032109846 modified "2023-09-23" @default.
- W3032109846 title "Effect of blood lipid levels on cerebrovascular hemodynamic indices in a young and middle-aged population" @default.
- W3032109846 doi "https://doi.org/10.3760/cma.j.issn.1674-0815.2018.05.005" @default.
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