Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032111186> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3032111186 endingPage "531" @default.
- W3032111186 startingPage "526" @default.
- W3032111186 abstract "ObjectiveTo investigate the significance of serum homocysteine (HCY) level in the patients with diabetic macroangiopathy, and analyze the related risk factors.MethodsCase control study. 279 diabetics (male 198, female 111) aged 59.6(55.0-67.0) were selected in Shanghai Zhongshan Hospital from May 2015 to February 2016. According to the medical history and Carotid intima-media thickness, they were divided into carotid artery disease group (137 cases), cardiovascular disease group (197 cases) and cerebrovascular disease group (29 cases). We detected veinal blood HCY , fasting blood glucose, glycated albumin, total bilirubin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, L-, gamma glutamyl transferase, urea nitrogen, creatinine, uric acid, cholesterol, three triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, glycosylated hemoglobin and albumin , creatinine in urine. The groups were compared with Mann-Whitney U test and χ2 test; Pearson correlation analysis was used to determine the correlations between HCY and other indicators; logistic regression model was used to analyze the risk factors of diabetic macroangiopathy and its subclasses; ROC curve was used to analyze the diagnostic value of HCY and uric acid in diabetic macroangiopathy.ResultsHCY in diabetic with macroangiopathy group was significant hiher than that in diabetic without macroangiopathy group 10.40(8.50-12.48) μmol/L 9.10(7.50-10.70) μmol/L, P<0.01). The incidence of diabetic macroangiopathy (χ2=7.030, P=0.030) and carotid artery lesions (χ2=7.258, P=0.027) was different in patients with different HCY levels. The correlation coefficients of HCY with urea nitrogen, creatinine, uric acid, urinary albumin/creatinine and estimated glomerular filtration rate (eGFR) were 0.340, 0.248, 0.278, 0.133, -0.369 (P<0.05), respectively. HCY was a risk factor for diabetic macroangiopathy, carotid plaque and cardiovascular disease; HCY, age and uric acid were independent risk factors for some of the diabetic macroangiopathy (P<0.05); HCY and UA had a certain diagnostic value for diabetic macroangiopathy(P<0.05).ConclusionsSerum HCY is a risk factor for diabetic macroangiopathy, and detection of HCY levels will contribute to the diagnosis and prevention of the disease.(Chin J Lab Med, 2017, 40: 526-531)Key words: Diabetic angiopathies; Homocysteine; Biological markers" @default.
- W3032111186 created "2020-06-05" @default.
- W3032111186 creator A5003085973 @default.
- W3032111186 creator A5012239404 @default.
- W3032111186 creator A5020229247 @default.
- W3032111186 creator A5057625959 @default.
- W3032111186 creator A5060027462 @default.
- W3032111186 creator A5081222791 @default.
- W3032111186 date "2017-07-11" @default.
- W3032111186 modified "2023-09-27" @default.
- W3032111186 title "The significance and risk factor analysis of homocysteine in diabetic patients with macroangiopathy" @default.
- W3032111186 doi "https://doi.org/10.3760/cma.j.issn.1009-9158.2017.07.011" @default.
- W3032111186 hasPublicationYear "2017" @default.
- W3032111186 type Work @default.
- W3032111186 sameAs 3032111186 @default.
- W3032111186 citedByCount "0" @default.
- W3032111186 crossrefType "journal-article" @default.
- W3032111186 hasAuthorship W3032111186A5003085973 @default.
- W3032111186 hasAuthorship W3032111186A5012239404 @default.
- W3032111186 hasAuthorship W3032111186A5020229247 @default.
- W3032111186 hasAuthorship W3032111186A5057625959 @default.
- W3032111186 hasAuthorship W3032111186A5060027462 @default.
- W3032111186 hasAuthorship W3032111186A5081222791 @default.
- W3032111186 hasConcept C126322002 @default.
- W3032111186 hasConcept C134018914 @default.
- W3032111186 hasConcept C2777090595 @default.
- W3032111186 hasConcept C2777180221 @default.
- W3032111186 hasConcept C2777538456 @default.
- W3032111186 hasConcept C2779881121 @default.
- W3032111186 hasConcept C2780306776 @default.
- W3032111186 hasConcept C50440223 @default.
- W3032111186 hasConcept C555293320 @default.
- W3032111186 hasConcept C71924100 @default.
- W3032111186 hasConcept C90924648 @default.
- W3032111186 hasConceptScore W3032111186C126322002 @default.
- W3032111186 hasConceptScore W3032111186C134018914 @default.
- W3032111186 hasConceptScore W3032111186C2777090595 @default.
- W3032111186 hasConceptScore W3032111186C2777180221 @default.
- W3032111186 hasConceptScore W3032111186C2777538456 @default.
- W3032111186 hasConceptScore W3032111186C2779881121 @default.
- W3032111186 hasConceptScore W3032111186C2780306776 @default.
- W3032111186 hasConceptScore W3032111186C50440223 @default.
- W3032111186 hasConceptScore W3032111186C555293320 @default.
- W3032111186 hasConceptScore W3032111186C71924100 @default.
- W3032111186 hasConceptScore W3032111186C90924648 @default.
- W3032111186 hasIssue "07" @default.
- W3032111186 hasLocation W30321111861 @default.
- W3032111186 hasOpenAccess W3032111186 @default.
- W3032111186 hasPrimaryLocation W30321111861 @default.
- W3032111186 hasRelatedWork W1603856712 @default.
- W3032111186 hasRelatedWork W2356419475 @default.
- W3032111186 hasRelatedWork W2357847450 @default.
- W3032111186 hasRelatedWork W2371989219 @default.
- W3032111186 hasRelatedWork W2374818002 @default.
- W3032111186 hasRelatedWork W2376172554 @default.
- W3032111186 hasRelatedWork W2380645747 @default.
- W3032111186 hasRelatedWork W2380847364 @default.
- W3032111186 hasRelatedWork W2383497901 @default.
- W3032111186 hasRelatedWork W2383983558 @default.
- W3032111186 hasRelatedWork W2387752593 @default.
- W3032111186 hasRelatedWork W2388368644 @default.
- W3032111186 hasRelatedWork W2392809328 @default.
- W3032111186 hasRelatedWork W2547559140 @default.
- W3032111186 hasRelatedWork W2549234517 @default.
- W3032111186 hasRelatedWork W2978584351 @default.
- W3032111186 hasRelatedWork W2981741519 @default.
- W3032111186 hasRelatedWork W2985330232 @default.
- W3032111186 hasRelatedWork W3029069305 @default.
- W3032111186 hasRelatedWork W3031595363 @default.
- W3032111186 hasVolume "40" @default.
- W3032111186 isParatext "false" @default.
- W3032111186 isRetracted "false" @default.
- W3032111186 magId "3032111186" @default.
- W3032111186 workType "article" @default.