Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032113277> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3032113277 endingPage "258" @default.
- W3032113277 startingPage "254" @default.
- W3032113277 abstract "ObjectiveTo observe the expression of ZNF139 and MMP-7 in endometrial adenocarcinoma tissues and discuss the correlation with clinical pathological significances.MethodsIn 71 patients diagnosed as endometrial adenocarcinoma, 71 cancer tissues(adenocarcinoma group) and 71 adjacent normal tiuues(adjacent cancer group) were collected in operations.Immunohistochemical methods was used to detect the expression of ZNF139 and MMP-7 in the two groups, the relationship between the two genes and communication with clinicopathological indexes were discussed.Western blot and qRT-PCR were used to detected the expression of ZNF139 and MMP-7 at protein and mRNA level.ResultsThe positive rates of ZNF139 was 66.20% in adenocarcinoma group, higher than in adjacent cancer group(21.42%, P=0.016); the positive rates of MMP-7 was 74.65% in adenocarcinoma group, higher than7 than in adjacent cancer group(26.76%, P=0.012). The expression of ZNF139 and MMP-7 was correlated with lymph node metastasis, muscle invasion and FIGO stage(P=0.028, 0.031; P=0.004, 0.016; P=0.008, 0.011). Spearman rank correlation analysis showed there was positive correlation between ZNF139 and MMP-7 in adenocarcinoma tissues(r=0.716, P=0.039). Western blot showed that ZNF139 and MMP-7 expression in adenocarcinoma group were higher than in adjacent cancer group(t=6.92, 7.34; P<0.01); qRT-PCR showed that ZNF139 mRNA and MMP-7 mRNA expression in adenocarcinoma group were higher than in adjacent cancer group(t=4.27, 4.06; P<0.05).ConclusionZNF139 and MMP-7 are correlated with malignant pathological characteristics in endometrial adenocarcinoma, they may modulate the malignant behavior together.Key words: Endometrial adenocarcinoma; Zinc finger protein 139; Matrix metalloproteinase 7" @default.
- W3032113277 created "2020-06-05" @default.
- W3032113277 creator A5049249421 @default.
- W3032113277 creator A5083130863 @default.
- W3032113277 date "2017-03-01" @default.
- W3032113277 modified "2023-09-24" @default.
- W3032113277 title "Significance and expression of zinc finger protein 139 and matrix metalloproteinase 7 in endometrial adenocarcinoma" @default.
- W3032113277 doi "https://doi.org/10.3760/cma.j.issn.1008-6315.2017.03.014" @default.
- W3032113277 hasPublicationYear "2017" @default.
- W3032113277 type Work @default.
- W3032113277 sameAs 3032113277 @default.
- W3032113277 citedByCount "0" @default.
- W3032113277 crossrefType "journal-article" @default.
- W3032113277 hasAuthorship W3032113277A5049249421 @default.
- W3032113277 hasAuthorship W3032113277A5083130863 @default.
- W3032113277 hasConcept C104317684 @default.
- W3032113277 hasConcept C109523444 @default.
- W3032113277 hasConcept C121608353 @default.
- W3032113277 hasConcept C126322002 @default.
- W3032113277 hasConcept C142724271 @default.
- W3032113277 hasConcept C143998085 @default.
- W3032113277 hasConcept C204232928 @default.
- W3032113277 hasConcept C207886595 @default.
- W3032113277 hasConcept C2776415932 @default.
- W3032113277 hasConcept C2777088508 @default.
- W3032113277 hasConcept C2779013556 @default.
- W3032113277 hasConcept C2781182431 @default.
- W3032113277 hasConcept C55493867 @default.
- W3032113277 hasConcept C71924100 @default.
- W3032113277 hasConcept C86803240 @default.
- W3032113277 hasConceptScore W3032113277C104317684 @default.
- W3032113277 hasConceptScore W3032113277C109523444 @default.
- W3032113277 hasConceptScore W3032113277C121608353 @default.
- W3032113277 hasConceptScore W3032113277C126322002 @default.
- W3032113277 hasConceptScore W3032113277C142724271 @default.
- W3032113277 hasConceptScore W3032113277C143998085 @default.
- W3032113277 hasConceptScore W3032113277C204232928 @default.
- W3032113277 hasConceptScore W3032113277C207886595 @default.
- W3032113277 hasConceptScore W3032113277C2776415932 @default.
- W3032113277 hasConceptScore W3032113277C2777088508 @default.
- W3032113277 hasConceptScore W3032113277C2779013556 @default.
- W3032113277 hasConceptScore W3032113277C2781182431 @default.
- W3032113277 hasConceptScore W3032113277C55493867 @default.
- W3032113277 hasConceptScore W3032113277C71924100 @default.
- W3032113277 hasConceptScore W3032113277C86803240 @default.
- W3032113277 hasIssue "3" @default.
- W3032113277 hasLocation W30321132771 @default.
- W3032113277 hasOpenAccess W3032113277 @default.
- W3032113277 hasPrimaryLocation W30321132771 @default.
- W3032113277 hasRelatedWork W119728110 @default.
- W3032113277 hasRelatedWork W2347328755 @default.
- W3032113277 hasRelatedWork W2350299591 @default.
- W3032113277 hasRelatedWork W2351579129 @default.
- W3032113277 hasRelatedWork W2352111241 @default.
- W3032113277 hasRelatedWork W2356883379 @default.
- W3032113277 hasRelatedWork W2357303114 @default.
- W3032113277 hasRelatedWork W2358156500 @default.
- W3032113277 hasRelatedWork W2359631863 @default.
- W3032113277 hasRelatedWork W2368940308 @default.
- W3032113277 hasRelatedWork W2369473237 @default.
- W3032113277 hasRelatedWork W2379302523 @default.
- W3032113277 hasRelatedWork W2382450328 @default.
- W3032113277 hasRelatedWork W2387210980 @default.
- W3032113277 hasRelatedWork W2387322089 @default.
- W3032113277 hasRelatedWork W2418239813 @default.
- W3032113277 hasRelatedWork W2977368081 @default.
- W3032113277 hasRelatedWork W3030062590 @default.
- W3032113277 hasRelatedWork W3032654991 @default.
- W3032113277 hasRelatedWork W3152343982 @default.
- W3032113277 hasVolume "33" @default.
- W3032113277 isParatext "false" @default.
- W3032113277 isRetracted "false" @default.
- W3032113277 magId "3032113277" @default.
- W3032113277 workType "article" @default.