Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032118067> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W3032118067 endingPage "153" @default.
- W3032118067 startingPage "153" @default.
- W3032118067 abstract "目的探讨天冬氨酸特异性半胱氨酸蛋白酶( Cystene -requiring aspartate protease,Caspase)在鼠肝缺血再灌注(Ischemic Reperfusion,IR) 损伤中的变化及缺血预处理(Ischemic Preconditioning,IP)的保护作用机制.方法 30只大鼠随机分为IR组、IP组及假手术组(S)组.检测再灌注术后3h血清AST、ALT 水平、肝组织caspase3活性、肝细胞凋亡指数(Apoptosis Index,AI)和电镜下超微结构改变.结果⑴血清AST、ALT改变:IP组和IR组较S组显著升高(P＜0.01),其中IR组升高最明显,与IP组比较差异有显著性(P＜0.01).⑵肝组织Caspase3活性,IR组和IP组较S组明显升高(P＜0.01),IR组最明显,与IP组比较差异显著(P＜0.01).⑶肝细胞AI S组未见明显调亡细胞,IR组和IP组AI差异有显著性(P＜0.01).⑷电镜IR组超微结构破坏明显,IP组相对较轻,S组基本正常.结论 IR损伤可激活Caspase3活性,促进肝细胞凋亡,从而加重肝脏损害,IP可明显减轻肝脏IR损伤,可能的机制之一是下调Caspase3的活性来抑制肝细胞调亡." @default.
- W3032118067 created "2020-06-05" @default.
- W3032118067 creator A5006648458 @default.
- W3032118067 creator A5038444070 @default.
- W3032118067 date "2003-02-20" @default.
- W3032118067 modified "2023-09-25" @default.
- W3032118067 title "Caspase 3 Activity of Ischemia Reperfusion Injury in Rats and The Protective Mechanism of Ischemic Preconditioning" @default.
- W3032118067 doi "https://doi.org/10.3760/cma.j.issn.1008-1372.2003.02.004" @default.
- W3032118067 hasPublicationYear "2003" @default.
- W3032118067 type Work @default.
- W3032118067 sameAs 3032118067 @default.
- W3032118067 citedByCount "0" @default.
- W3032118067 crossrefType "journal-article" @default.
- W3032118067 hasAuthorship W3032118067A5006648458 @default.
- W3032118067 hasAuthorship W3032118067A5038444070 @default.
- W3032118067 hasConcept C111472728 @default.
- W3032118067 hasConcept C138885662 @default.
- W3032118067 hasConcept C164705383 @default.
- W3032118067 hasConcept C2779311647 @default.
- W3032118067 hasConcept C2780114680 @default.
- W3032118067 hasConcept C2908780116 @default.
- W3032118067 hasConcept C541997718 @default.
- W3032118067 hasConcept C71924100 @default.
- W3032118067 hasConcept C89611455 @default.
- W3032118067 hasConcept C98274493 @default.
- W3032118067 hasConceptScore W3032118067C111472728 @default.
- W3032118067 hasConceptScore W3032118067C138885662 @default.
- W3032118067 hasConceptScore W3032118067C164705383 @default.
- W3032118067 hasConceptScore W3032118067C2779311647 @default.
- W3032118067 hasConceptScore W3032118067C2780114680 @default.
- W3032118067 hasConceptScore W3032118067C2908780116 @default.
- W3032118067 hasConceptScore W3032118067C541997718 @default.
- W3032118067 hasConceptScore W3032118067C71924100 @default.
- W3032118067 hasConceptScore W3032118067C89611455 @default.
- W3032118067 hasConceptScore W3032118067C98274493 @default.
- W3032118067 hasIssue "2" @default.
- W3032118067 hasLocation W30321180671 @default.
- W3032118067 hasOpenAccess W3032118067 @default.
- W3032118067 hasPrimaryLocation W30321180671 @default.
- W3032118067 hasRelatedWork W1995426253 @default.
- W3032118067 hasRelatedWork W2061769561 @default.
- W3032118067 hasRelatedWork W2349695577 @default.
- W3032118067 hasRelatedWork W2358636422 @default.
- W3032118067 hasRelatedWork W2361568246 @default.
- W3032118067 hasRelatedWork W2361774682 @default.
- W3032118067 hasRelatedWork W2366101669 @default.
- W3032118067 hasRelatedWork W2366683468 @default.
- W3032118067 hasRelatedWork W2367137880 @default.
- W3032118067 hasRelatedWork W2369384241 @default.
- W3032118067 hasRelatedWork W2375681809 @default.
- W3032118067 hasRelatedWork W2381819720 @default.
- W3032118067 hasRelatedWork W2382144196 @default.
- W3032118067 hasRelatedWork W2394166475 @default.
- W3032118067 hasRelatedWork W2909913329 @default.
- W3032118067 hasRelatedWork W3028949388 @default.
- W3032118067 hasRelatedWork W3032218250 @default.
- W3032118067 hasRelatedWork W3111247077 @default.
- W3032118067 hasRelatedWork W2766057915 @default.
- W3032118067 hasRelatedWork W3031337484 @default.
- W3032118067 hasVolume "5" @default.
- W3032118067 isParatext "false" @default.
- W3032118067 isRetracted "false" @default.
- W3032118067 magId "3032118067" @default.
- W3032118067 workType "article" @default.