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- W3032120090 abstract "目的制作与临床病因相符的肺出血动物模型,探讨氧自由基(OFR)在肺出血中的损伤作用.方法用低温缺氧后复温供氧的方法,以新生Wistar大鼠制作肺出血模型.以大体、光镜及电镜方法观察肺组织病理并测定肺组织MDA及SOD变化.结果①随低温缺氧时间延长,肺出血可从点状向局灶并向弥漫性方向发展.②随肺出血加重,肺水肿趋严重;肺血管内皮细胞(PVEC)、细胞间隙连接(GJ)、基底膜(BM)及Ⅱ型上皮细胞(TⅡ)受损;MDA不断增加,SOD不断消耗.结论①低温缺氧后复温供氧能成功制作出与临床病因相符的新生鼠肺出血模型.②肺出血与OFR损伤有关:低温缺氧期GJ受损,致肺血管通透性增加而发生肺水肿.复温供氧期PVEC、GJ、BM受损,毛细血管内红细胞外渗至肺泡腔而发生肺出血." @default.
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- W3032120090 date "2002-04-20" @default.
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- W3032120090 title "The relationship between the pathomorphism and the variation of the oxygenic free radical in pulmonary tissue of newborn rats with pulmonary hemorrhage" @default.
- W3032120090 doi "https://doi.org/10.3760/cma.j.issn.1673-4912.2002.04.009" @default.
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