Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032123181> ?p ?o ?g. }
- W3032123181 endingPage "1316" @default.
- W3032123181 startingPage "1303" @default.
- W3032123181 abstract "Abstract Metabolic alterations in cancer represent convergent effects of oncogenic mutations. We hypothesized that a metabolism-restricted genetic screen, comparing normal primary mouse hematopoietic cells and their malignant counterparts in an ex vivo system mimicking the bone marrow microenvironment, would define distinctive vulnerabilities in acute myeloid leukemia (AML). Leukemic cells, but not their normal myeloid counterparts, depended on the aldehyde dehydrogenase 3a2 (Aldh3a2) enzyme that oxidizes long-chain aliphatic aldehydes to prevent cellular oxidative damage. Aldehydes are by-products of increased oxidative phosphorylation and nucleotide synthesis in cancer and are generated from lipid peroxides underlying the non–caspase-dependent form of cell death, ferroptosis. Leukemic cell dependence on Aldh3a2 was seen across multiple mouse and human myeloid leukemias. Aldh3a2 inhibition was synthetically lethal with glutathione peroxidase-4 (GPX4) inhibition; GPX4 inhibition is a known trigger of ferroptosis that by itself minimally affects AML cells. Inhibiting Aldh3a2 provides a therapeutic opportunity and a unique synthetic lethality to exploit the distinctive metabolic state of malignant cells." @default.
- W3032123181 created "2020-06-05" @default.
- W3032123181 creator A5009763658 @default.
- W3032123181 creator A5013328806 @default.
- W3032123181 creator A5021292616 @default.
- W3032123181 creator A5022639028 @default.
- W3032123181 creator A5025835931 @default.
- W3032123181 creator A5029861590 @default.
- W3032123181 creator A5031651397 @default.
- W3032123181 creator A5035618234 @default.
- W3032123181 creator A5038580050 @default.
- W3032123181 creator A5039045747 @default.
- W3032123181 creator A5039100978 @default.
- W3032123181 creator A5040568259 @default.
- W3032123181 creator A5040956966 @default.
- W3032123181 creator A5047214022 @default.
- W3032123181 creator A5048457458 @default.
- W3032123181 creator A5051881453 @default.
- W3032123181 creator A5052285917 @default.
- W3032123181 creator A5054970430 @default.
- W3032123181 creator A5060853214 @default.
- W3032123181 creator A5062048275 @default.
- W3032123181 creator A5075964850 @default.
- W3032123181 creator A5082899763 @default.
- W3032123181 creator A5083528886 @default.
- W3032123181 creator A5083648953 @default.
- W3032123181 creator A5086312950 @default.
- W3032123181 creator A5088797237 @default.
- W3032123181 creator A5088813832 @default.
- W3032123181 creator A5089906227 @default.
- W3032123181 date "2020-09-10" @default.
- W3032123181 modified "2023-10-17" @default.
- W3032123181 title "Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers" @default.
- W3032123181 cites W1967358345 @default.
- W3032123181 cites W1973072912 @default.
- W3032123181 cites W1975468172 @default.
- W3032123181 cites W1997183854 @default.
- W3032123181 cites W2002213310 @default.
- W3032123181 cites W2004899801 @default.
- W3032123181 cites W2017746705 @default.
- W3032123181 cites W2022335352 @default.
- W3032123181 cites W2028872385 @default.
- W3032123181 cites W2031473795 @default.
- W3032123181 cites W2035571161 @default.
- W3032123181 cites W2047122678 @default.
- W3032123181 cites W2061064967 @default.
- W3032123181 cites W2064484411 @default.
- W3032123181 cites W2086137541 @default.
- W3032123181 cites W2097259163 @default.
- W3032123181 cites W2109336877 @default.
- W3032123181 cites W2118451648 @default.
- W3032123181 cites W2121469024 @default.
- W3032123181 cites W2122659245 @default.
- W3032123181 cites W2163018106 @default.
- W3032123181 cites W2171074759 @default.
- W3032123181 cites W2181347641 @default.
- W3032123181 cites W2396911170 @default.
- W3032123181 cites W2461476252 @default.
- W3032123181 cites W2508296626 @default.
- W3032123181 cites W2519842257 @default.
- W3032123181 cites W2520159331 @default.
- W3032123181 cites W2585315580 @default.
- W3032123181 cites W2663635603 @default.
- W3032123181 cites W2727828415 @default.
- W3032123181 cites W2753134417 @default.
- W3032123181 cites W2755975022 @default.
- W3032123181 cites W2767055857 @default.
- W3032123181 cites W2808682367 @default.
- W3032123181 cites W2901585624 @default.
- W3032123181 cites W2913137771 @default.
- W3032123181 cites W2934128479 @default.
- W3032123181 cites W4233413831 @default.
- W3032123181 doi "https://doi.org/10.1182/blood.2019001808" @default.
- W3032123181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7483435" @default.
- W3032123181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32458004" @default.
- W3032123181 hasPublicationYear "2020" @default.
- W3032123181 type Work @default.
- W3032123181 sameAs 3032123181 @default.
- W3032123181 citedByCount "55" @default.
- W3032123181 countsByYear W30321231812020 @default.
- W3032123181 countsByYear W30321231812021 @default.
- W3032123181 countsByYear W30321231812022 @default.
- W3032123181 countsByYear W30321231812023 @default.
- W3032123181 crossrefType "journal-article" @default.
- W3032123181 hasAuthorship W3032123181A5009763658 @default.
- W3032123181 hasAuthorship W3032123181A5013328806 @default.
- W3032123181 hasAuthorship W3032123181A5021292616 @default.
- W3032123181 hasAuthorship W3032123181A5022639028 @default.
- W3032123181 hasAuthorship W3032123181A5025835931 @default.
- W3032123181 hasAuthorship W3032123181A5029861590 @default.
- W3032123181 hasAuthorship W3032123181A5031651397 @default.
- W3032123181 hasAuthorship W3032123181A5035618234 @default.
- W3032123181 hasAuthorship W3032123181A5038580050 @default.
- W3032123181 hasAuthorship W3032123181A5039045747 @default.
- W3032123181 hasAuthorship W3032123181A5039100978 @default.
- W3032123181 hasAuthorship W3032123181A5040568259 @default.
- W3032123181 hasAuthorship W3032123181A5040956966 @default.
- W3032123181 hasAuthorship W3032123181A5047214022 @default.