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- W3032127136 abstract "目的观察交替化疗与多药联合化疗治疗晚期儿童神经母细胞瘤的疗效,毒性反应及对生存期的影响.方法对29例晚期神经母细胞瘤的患儿给予术前或术后化疗,14例采用COA/VIP或VP方案交替化疗共155疗程,15例采用COPE等多药联合化疗共84疗程.结果交替化疗组14例可评价疗效13例,CR 0,PR12例,NC1例,PD 0.有效率12/13(92.3%).化疗后手术完整切除率10/13(76.9%).多药联合化疗组15例,可评价疗效11例,CR1例,PR5例,NC3例,PD2例,有效率6/11(54.5%).化疗后手术切除率为5/11(45.5%).两组比较P＜0.05(X2检验),化疗的毒性反应主要表现为骨髓抑制,恶心呕吐等,均为可逆性.两组生存期比较经秩和检验P＞0 05无统计学差异.结论交替化疗较之多药联合化疗治疗晚期儿童神经母细胞瘤疗效好,手术切除率高.毒性反应大致相同,两组生存期也大致相同." @default.
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- W3032127136 date "2001-07-15" @default.
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- W3032127136 title "Alternate or multidrug combined chemotherapy for advanced neuroblastoma" @default.
- W3032127136 doi "https://doi.org/10.3760/cma.j.issn.0253-3006.2001.04.004" @default.
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