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- W3032128252 abstract "ObjectiveTo investigate the inhibitory effect of aqueous extract of Taxus chinensis. var (AETC) combining Cisplatin (DDP) on vitro cultured human lung carcinoma A549 cells, and the effects on resistance genes.MethodsThe A549 cells were divided into different concentrations of DDP groups, different concentrations of AETC groups, and blank group, and drug effect of 48 h with the method of cell counting kit-8 (CCK-8) and the effect on cell survival were detected. Based on the above results, then A549 cells were divided into DDP combining different concentrations of AETC groups, DDP group, blank control group, and drug effect of 48 h with the method of CCK-8 and the effect on cells survival were detected. The gene expressions of adenosine triphosphate (ATP)-binding cassette subfamily B member 1 trans-porter (ABCB1), ABCG2, and ABCC1 were examined by polymerase chain reaction (RT-PCR).ResultsCisplatin 12 μg/ml (DDP), DDP+ ATEC 400 μg/ml, DDP+ ATEC 800 μg/ml, DDP+ ATEC 1 200 μg/ml, DDP+ ATEC 1 600 μg/ml, A549 cell inhibition rate of each group was 44.36%, 69.61%, 74.73%, 80.10%, and 74.73%, respectively; Different concentrations of AETC combining DDP could decrease the resistance related gene ABCC1, ABCB1 expressions, and correlated to the dose. AETC combining DDP showed no effects on ABCG2 gene expression.ConclusionsAETC combining DDP could inhibit the growth of A549 cells, and decrease the resistance-related gene ABCC1, ABCB1 expressions.Key words: Taxus; Cisplatin/AD; Lung neoplasms/ZJ/ME; Cell proliferation/DE; ATP-binding cassette transporters/ME" @default.
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- W3032128252 date "2016-12-20" @default.
- W3032128252 modified "2023-09-23" @default.
- W3032128252 title "Study on inhibitory action of proliferation of human lung carcinoma A549 cells with aqueous extract of Taxus chinensis. var combining Cisplatin and the effects on resistance genes" @default.
- W3032128252 doi "https://doi.org/10.3760/cma.j.issn.1008-1372.2016.12.008" @default.
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