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- W3032163721 abstract "Background: Filler have been used for aesthetic for many years, but there are also a lot granulomacase reported in several years. Filler makes foreign body reaction in our body and granuloma forsome people. The aim of this study was to analyze the pathogenesis of silicone granuloma includingits correlation with immune inflammatory responses and tolerance.Method: Cross sectional research was designed to compare 2 groups of 31granuloma tissue with silicone injection and 37 normal skin (control). Responseimmune to the filler through the expression of TNF-a, IFN-g , IL-10 cytokines, IDOenzyme. The experimental study cultured whole blood of the case and controlpatients and measured the level of TNF-a, IFN-g , IL-10 cytokines and IDO enzyme.The study was conducted in JMB specialist clinics, FMIPA, FKUI, FKUA, and Eijkmanfoundation from the year 2012 to 2014.Result: Patients with granuloma because of filler had higher level of proinflammatory cytokines intheir blood. The ratio of TNF-a/IL-10 and TNF-a/IDO in blood is significant different with controlnormal. It is demonstrating the function of antiinflammation or immune tolerance working through IL-10 and IDO.Conclusion:. IL-10 collaborates with IDO enzyme in the immune tolerance caused by siliconeinjection. TNF-a in blood and anti inflammatory cytokines can be utilized as predictors to assess theresulting immune response due to silicone injection." @default.
- W3032163721 created "2020-06-05" @default.
- W3032163721 creator A5020629363 @default.
- W3032163721 date "2017-01-01" @default.
- W3032163721 modified "2023-09-27" @default.
- W3032163721 title "Immunology Behind the Dermal Filler" @default.
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